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P-802 - the Structure and Connectivity of Brain Regions Involved in Emotion Processing are Modulated by 5httlpr x Comt Epistasis

Published online by Cambridge University Press:  15 April 2020

S.A. Surguladze ,
W. El-Hage ,
J. Radua ,
G.C. Monté ,
V. Villalta Gil  and
M.L. Phillips
S.A. Surguladze
Affiliation:
Psychosis Studies, King's College London Institute of Psychiatry, London, UK Cygnet Health Care, London, UK
W. El-Hage
Affiliation:
Inserm U930 ERL CNRS 3106, Université François Rabelais, CHRU Tours, Tours, France
J. Radua
Affiliation:
FIDMAG, CIBERSAM, Sant Boi de Llobregat, Barcelona, Spain
G.C. Monté
Affiliation:
FIDMAG, CIBERSAM, Sant Boi de Llobregat, Barcelona, Spain
V. Villalta Gil
Affiliation:
Unitat de Recerca, Sant Joan de Déu Serveis de Salut Mental, Barcelona, Spain
M.L. Phillips
Affiliation:
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

Abstract

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Introduction

Imaging genetic studies provide for the possibility to uncover endophenotypes for neuropsychiatric disorders.

Objectives

To establish neuroimaging correlates of the joint effect of serotonergic (5-HTTLPR) and dopaminergic (COMT) genes.

Aims

To examine an interaction of 5-HTTLPR and COMT markers on effective connectivity and regional brain volume in healthy individuals.

Methods

Ninety one healthy Caucasian adults underwent functional magnetic resonance imaging (fMRI) and structural MRI. In fMRI study the participants were presented with videoclips of dynamic emotional facial expressions of fear, sadness, happiness and anger. The effective connectivity within the emotion processing circuitry was assessed with Granger causality method. In the structural neuroimaging part of the study we applied diffeomorphic anatomic registration through exponentiated Lie algebra (DARTEL) whole-brain voxel-based morphometry (VBM).

Results

In fear processing condition, an interaction between 5-HTTLPR (S) and COMT(met) low activity alleles was associated with reduced effective connectivity within the facial emotion processing circuitry.

The results of the structural data analysis showed an interaction of COMT and 5-HTTLPR genotypes with regional grey matter volume in bilateral parahippocampal gyrus, amygdala, hippocampus, cerebellum and right putamen. In particular, the gray matter volume in these regions was smaller in individuals who were both COMT-met and 5-HTTLPR-S carriers, as compared to those carrying either 5-HTTLPR-L/L, or COMT-val/val.

Conclusions

The epistatic effect of COMT-met and 5-HTTLPR-S markers impacts on both the brain function and structure and may underlie an inefficient emotion regulation.

Type
Abstract
Information
European Psychiatry , Volume 27 , Issue S1: Abstracts of the 20th European Congress of Psychiatry , 2012 , pp. 1
Copyright
Copyright © European Psychiatric Association 2012
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