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P-778 - S100B Serum Protein Does not Have a Circadian Rhythm in Healthy Subjects

Published online by Cambridge University Press:  15 April 2020

A.L. Morera-Fumero ,
P. Abreu-Gonzalez ,
M. Henry-Benitez ,
S. Yelmo-Cruz ,
E. Diaz-Mesa  and
R. Gracia-Marco
A.L. Morera-Fumero
Affiliation:
Department of Internal Medicine, Dermatology and Psychiatry, School of Medicine, University of La Laguna, Santa Cruz de Tenerife, La Laguna, Spain
P. Abreu-Gonzalez
Affiliation:
Department of Physiology, University of La Laguna, La Laguna, Spain
M. Henry-Benitez
Affiliation:
Department of Psychiatry, University Hospital of the Canary Islands, La Laguna, Spain
S. Yelmo-Cruz
Affiliation:
Department of Psychiatry, University Hospital of the Canary Islands, La Laguna, Spain
E. Diaz-Mesa
Affiliation:
Department of Psychiatry, University Hospital of the Canary Islands, La Laguna, Spain
R. Gracia-Marco
Affiliation:
Department of Psychiatry, University Hospital of the Canary Islands, La Laguna, Spain

Abstract

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Introduction:

Circadianity is a characteristic of several human biological variables, such as testosterone, melatonin and cortisol. There is little information whether or not S100B serum protein presents a circadian rhythm.

Material and methods:

44 healthy subjects (24 female and 20 male, age 39.7 ± 9.4) participated in the study. Blood was sampled in July at 09:00, 12:00 and 24:00 h. Blood was centrifuged and serum was aliquot in Eppendorf tubes and frozen at −70° C. Serum S100B was measured by ELISA.

Results:

Serum S100B concentrations at 09:00 (56.3 ± 18.1 pg/ml), 12:00 (53.8 ± 23.1 pg/ml) and 24:00 h. (55.3 ± 20.3 pg/ml) were not significantly different.

Conclusions:

Our results point to the absence of a circadian rhythm of S100B serum protein concentrations. the lack of the disadvantage may allow researchers on this area to sample subjects at any time of the day.

Type
Abstract
Information
European Psychiatry , Volume 27 , Issue S1: Abstracts of the 20th European Congress of Psychiatry , 2012 , pp. 1
Copyright
Copyright © European Psychiatric Association 2012
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