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P-728 - Does Aripiprazole Deserve a Second Chance in Parkinson's Disease Psychosis?

Published online by Cambridge University Press:  15 April 2020

P. Michielsen ,
M. Arts  and
M. Morrens
P. Michielsen
Affiliation:
GGZ Westelijk Noord Brabant, Halsteren, the Netherlands
M. Arts
Affiliation:
Elderly Psychiatry, UMCG Groningen, Groningen, the Netherlands
M. Morrens
Affiliation:
CAPRI, Antwerpen, Belgium

Abstract

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Introduction:

A case report of a 55 year old male, previously diagnosed with Parkinson's Disease(PD), presenting cognitive deficit and psychotic features on admission, is presented. Aripiprazole, despite not being first choice for this indication, was the only antipsychtoic drug to improve psychotic symtoms without worsening motor movement and improving cognitive functioning. A literature review on treatment options in PD psychosis is presented.

Objectives:

Describe the triad Parkinson's Disease/Cognitive Decline/Psychosis and review treatment options.

Aims:

To explain the unique activity of aripirazole in PD Psychosis on the grounds of existing reasearch evidence and neurotransmitter activity.

Methods:

A case report is described and literature reviewed.

Results:

Due to its unique receptor binding profile, specifically on 5HTA1 receptors, M1 receptors and its affinity for D2 receptors, aripiprazole seems a promising drug in the treatment of PD psychosis when cognitive decline is equally present. Future prospective studies are needed to test this hypothesis.

Type
Abstract
Information
European Psychiatry , Volume 27 , Issue S1: Abstracts of the 20th European Congress of Psychiatry , 2012 , pp. 1
Copyright
Copyright © European Psychiatric Association 2012
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