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P-72 - the Influence of Single Dose of Methadone on the qt Value in Patients From the Substitution Program

Published online by Cambridge University Press:  15 April 2020

E. Nowińska ,
P. Litmanowski ,
E. Laskowska ,
J. Feit ,
P. Walecki ,
K. Pasgreta ,
M. Ziółkowski  and
E. Gorzelańczyk
E. Nowińska
Affiliation:
Department of Theoretical Basis of Bio-Medical Sciences and Medical Informatics
P. Litmanowski
Affiliation:
Department of Theoretical Basis of Bio-Medical Sciences and Medical Informatics
E. Laskowska
Affiliation:
Collegium Medicum of Nicolaus Copernicus University in Torun
J. Feit
Affiliation:
Non-Public Health Care Center Sue Ryder Home, Collegium Medicum of Nicolaus Copernicus University in Torun, Bydgoszcz
P. Walecki
Affiliation:
Faculty of Medicine, Jagiellonian University Medical College, Krakow
K. Pasgreta
Affiliation:
Department of Theoretical Basis of Bio-Medical Sciences and Medical Informatics
M. Ziółkowski
Affiliation:
Department of Psychiatry Nursing, Collegium Medicum of Nicolaus Copernicus University in Torun, Bydgoszcz
E. Gorzelańczyk
Affiliation:
Institute of Psychology, Polish Academy of Sciences, Warszawa, Poland

Abstract

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Introduction

Methadone treatment may cause prolongation of QT/QTc.

Aims/ objectives

This study aims to assess the impact of a single dose of methadone on the value of the QT in the patients from the substitution program.

Methods

Participants: 37 people (10women and 27men) treated with methadone in the substitution program. The average age of respondents was 35 ± 9 years old (min.21, max.59), the mean time of addiction 16 ± 8 years, mean dose of methadone was 80 ± 18 ml. The control group: 17 patients (6men and 11women), healthy, non-addicted to drugs. The average age of group was 29 ± 6 years. QT and QTc (ECG) were measured automatically. The study was performed before and about 60minutes after the administration of a single dose of methadone.

Results

There is a statistically significant difference between QTc values before and after the administration of a single dose of methadon (p = 0.006). Comparison of the average increase in QTc values in each group, showed that the patients taking methadone up to 70 ml (15.21 ms) had the highest increase, and those receiving a minimum of 90 ml (4 ms) had the lowest increase.

It was found that the QTc value is statistically significantly greater in patients after the intake of methadone (p = 0.048). The average QTc value obtained in these groups differed by 16.13 ms.

Conclusions

The analysis of the occurrence of statistically significant differences of QTc values before and after the administration of a single dose of methadone shows that methadone causes QT prolongation in the ECG in opioids addicted patients from the substitution program.

Type
Abstract
Information
European Psychiatry , Volume 27 , Issue S1: Abstracts of the 20th European Congress of Psychiatry , 2012 , pp. 1
Copyright
Copyright © European Psychiatric Association 2012
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