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P-708 - Genetic Risk Factors for Interferon-alpha Induced Depression

Published online by Cambridge University Press:  15 April 2020

R. Martín-Santos ,
R. Navinés ,
M. Udina ,
D. Giménez ,
J. Moreno ,
P. Castellví ,
K. Langhor ,
F. Gutiérrez ,
E. Gómez  and
M. Gratacòs
...Show all authors
R. Martín-Santos
Affiliation:
Department of Psychiatry, Institute of Clinical Neuroscience, Hospital Clínic, UB, IDIBAPS, CIBERSAM
R. Navinés
Affiliation:
Department of Psychiatry, Institute of Clinical Neuroscience, Hospital Clínic, UB, IDIBAPS, CIBERSAM Hepatology Unit, Hospital del Mar, IMIM, UAB
M. Udina
Affiliation:
Department of Psychiatry, Institute of Clinical Neuroscience, Hospital Clínic, UB, IDIBAPS, CIBERSAM
D. Giménez
Affiliation:
Hepatology Unit, Hospital del Mar, IMIM, UAB
J. Moreno
Affiliation:
Department of Psychiatry, Institute of Clinical Neuroscience, Hospital Clínic, UB, IDIBAPS, CIBERSAM
P. Castellví
Affiliation:
Department of Psychiatry, Institute of Clinical Neuroscience, Hospital Clínic, UB, IDIBAPS, CIBERSAM Hepatology Unit, Hospital del Mar, IMIM, UAB
K. Langhor
Affiliation:
Statistic Department, UPC
F. Gutiérrez
Affiliation:
Department of Psychiatry, Institute of Clinical Neuroscience, Hospital Clínic, UB, IDIBAPS, CIBERSAM
E. Gómez
Affiliation:
Department of Psychiatry, Institute of Clinical Neuroscience, Hospital Clínic, UB, IDIBAPS, CIBERSAM
M. Gratacòs
Affiliation:
Center of Genomic Regulation, PRBB, Barcelona, Spain
M. Valdés
Affiliation:
Department of Psychiatry, Institute of Clinical Neuroscience, Hospital Clínic, UB, IDIBAPS, CIBERSAM
R. Solà
Affiliation:
Hepatology Unit, Hospital del Mar, IMIM, UAB

Abstract

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Background/aims

Chronic hepatitis C infection (CHC) represents a public health problem that affects around 3% of population worldwide. Pegylated Interferon-alpha (PegIFN-α) and Ribavirin (RBV) is the recommended treatment reaching about 40–80% of sustained virological response. However, a common treatment side-effect is induced-depression that impairs patient's quality of life and treatment adherence (1,2). This paper showed polymorphisms in HTR1A, NCR1, TPH2 genes as predictive variables of IFN-induced depression.

Material/methods

396 consecutive, euthymic, CHC outpatients treated with PegIFN-α/RBV were included. Patients were assessed at baseline, 4, 12, 24 and 48 weeks of treatment using PHQ and MINI-DSM-IV-R interview to diagnose depression. Survival analysis was performed. in the univariated analysis functions were compared using logrank test. Significative variables (0.1 level) were extracted for the multivariated model, using a Weibull regression model.

Results:

The incidence of induced-depression along the treatment was 39.4%. Polimorphisms on HTR1A (P = 0.0104), TPH2 (P = 0.0231) and NRC1 (P = 0.0702) genes predicted IFN-induced depression.

Conclusions:

Genes related with serotonine and inflamation system may play an important role in the pathogenesis of IFN-induced depression. Knowledge of predictive variables for IFN-induced depression may help to better manage patients at risk.

Type
Abstract
Information
European Psychiatry , Volume 27 , Issue S1: Abstracts of the 20th European Congress of Psychiatry , 2012 , pp. 1
Copyright
Copyright © European Psychiatric Association 2012

References

Bibliography:

Martín-Santos, R., et al.De Novo Depression and Anxiety Disorders and Influence on Adherence During Peginterferon-alpha-2a and Ribavirin Treatment in Patients With Hepatitis c. Aliment Pharmacol Ther 2008; 27: 257–26510.1111/j.1365-2036.2007.03568.xCrossRefGoogle ScholarPubMed
Mathew, A., et al.Improvement in Quality of Life Measures in Patients With Refractory Hepatitis c,responding to Re-treatment With Pegifn-alpha-2b and Ribavirin. Health Qual Life Outcomes 2006; 4: 3010.1186/1477-7525-4-30CrossRefGoogle Scholar
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