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P-692 - Hyperprolactinaemia and Psychosis

Published online by Cambridge University Press:  15 April 2020

E.N. Rizos
Affiliation:
2nd Psychiatric Dpt, Athen, Greece
E. Tsigaropoulou
Affiliation:
2nd Psychiatric Dpt, Athen, Greece
M. Peppa
Affiliation:
University of Athen, Medical School, Athen, Greece
P. Ferentinos
Affiliation:
2nd Psychiatric Dpt, Athen, Greece
C. Zompola
Affiliation:
2nd Psychiatric Dpt, Athen, Greece
L. Lykouras
Affiliation:
2nd Psychiatric Dpt, Athen, Greece

Abstract

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Objective:

Hyperprolactinaemia causes hypogonadotropic hypogonadism. Hyperprolactinaemia could be pre-existing in some patients with schizophrenia. Dopamine is the most important prolactin inhibiting factor, while dopaminergic hyperactivity has been implicated to the pathophysiology of psychosis.

Method:

We present the case of a patient with hypogonadism secondary to chronic, untreated hyperprolactinaemia who developed acute psychotic symptoms.

Results:

Psychotic symptoms resolved soon after treatment with aripiprazole in conjunction with cabergoline, with a concomitant decrease in serum prolactin levels.

Conclusion:

An interesting cause effect relationship of hyperprolactinaemia and psychosis has been suggested

Type
Abstract
Copyright
Copyright © European Psychiatric Association 2012
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