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P-542 - Insulin-like Growth Factor 1 Receptor Gene Expression in Patients With Subsyndromal Symptomatic Depression

Published online by Cambridge University Press:  15 April 2020

Z. Yi ,
Z. Li ,
C. Zhang ,
W. Hong ,
C. Yuan ,
Z. Wu ,
S. Yu  and
Y. Fang
Z. Yi
Affiliation:
Shanghai Mental Health Center, Shanghai, China
Z. Li
Affiliation:
Shanghai Mental Health Center, Shanghai, China
C. Zhang
Affiliation:
Shanghai Mental Health Center, Shanghai, China
W. Hong
Affiliation:
Shanghai Mental Health Center, Shanghai, China
C. Yuan
Affiliation:
Shanghai Mental Health Center, Shanghai, China
Z. Wu
Affiliation:
Shanghai Mental Health Center, Shanghai, China
S. Yu
Affiliation:
Shanghai Mental Health Center, Shanghai, China
Y. Fang
Affiliation:
Shanghai Mental Health Center, Shanghai, China

Abstract

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Objective:

To study the relationship between insulin-like growth factor 1 receptor (IGF1R)and subsyndromal symptomatic depression (SSD).

Methods:

In this case-control study, real-time quantitative reverse transcriptase polymerase chain reaction (RT-qPCR) with TaqMan MGB was used to analyzing the differences of IGF1R gene mRNA expression in peripheral leukocytes between subsyndromal symptomatic depression group(n = 47) and healthy controls(n = 52). At the same time Hamilton Depression Rating Scale -17(HAMD17) were assessed.

Results:

IGF1R gene mRNA expression was 0.21 ± 0.11 in SSD group, 0.56 ± 0.37 in healthy group, and there was significant difference between both groups on IGF1R expression(z = 39.54, P < 0.001). the expression levels of IGF1R in SSD patients was not correlated with Hamilton score(r = −0.292, p = 0.275).

Conclusion:

This study suggested that the decreased expression of IGF1R were related with the pathophysiology of SSD.

Type
Abstract
Information
European Psychiatry , Volume 27 , Issue S1: Abstracts of the 20th European Congress of Psychiatry , 2012 , pp. 1
Copyright
Copyright © European Psychiatric Association 2012
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