Depression as a disease of modern times is constantly growing and it is regarded as a global, medical, individual and economic problem. Special importance have major depressive episodes (first or recurrent) with resistance to pharmacotherapy with antidepressants.

Main goal of this paper is to demonstrate the realibility of using the antidepressant with dual mechanism of action (bupropion).

Case study of elderly female patient of CMHC Prijedor with recurrent major depressive episode from author's practice and using data from a patient's file, with follow up period of 28 weeks after the first visit at CMHC Prijedor.

After resistance on first-line pharmacotherapy (SSRI antidepressant) we achieved a positive development and progressive improvement of patient's condition with better involvement to other parts of the therapeutic process (psycho- and socio-therapy) after 4 weeks of use of bupropion in a single daily dose of 150 mg [1][2].

Bupropion is a drug of choice for the treatment of major depressive episode, especially for inhibited depression, and in a single daily dose of 150 mg is antidepressant of choice for the elderly with depression [3].