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P-40 - Lack of Association Between the Val158met Catechol-o-methyltransferase Gene Polymorphism and Methamphetamine Dependence

Published online by Cambridge University Press:  15 April 2020

L. Hosak ,
O. Sery ,
M. Beranek  and
M. Alda
L. Hosak
Affiliation:
Dept. of Psychiatry, Charles University in Prague, Faculty of Medicine and University Hospital, Hradec Kralove
O. Sery
Affiliation:
Laboratory of Neurobiology and Molecular Psychiatry, Dept. of Biochemistry, Faculty of Science, Masaryk University, Brno
M. Beranek
Affiliation:
Institute of Clinical Biochemistry and Diagnostics, Charles University in Prague, Faculty of Medicine and University Hospital, Hradec Kralove, Czech Republic
M. Alda
Affiliation:
Dept. of Psychiatry, Dalhousie University, Halifax, NS, Canada

Abstract

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Introduction

About 25 000 serious methamphetamine abusers live in the Czech Republic among the total population of 10 million. Dependence on methamphetamine is markedly related to the brain neurotransmitter dopamine, metabolised by catechol-O-methyltransferase enzyme.

Objectives

The objective of our study was to deepen our knowledge on the genetic background of methamphetamine dependence.

Aims

The main aim of the study was to ascertain whether the Val158Met catechol-O-methyltransferase gene polymorphism is associated with methamphetamine dependence in the Czech Republic.

Methods

One hundred and twenty-three subjects dependent on methamphetamine (women N = 44), parents of sixty-seven dependent individuals, and four hundred healthy controls (women N = 250) were involved into the study. We performed a population-based as well as family-based genetic association studies.

Results

We did not find any significant association between the Val158Met catechol-O-methyltransferase gene polymorphism and methamphetamine dependence using the population-based or family-based design (P = 0.41-0.66; Chi-Square Test or UNPHASED program, Version 3.1.4, respectively). We found a trend toward a statistically significant difference between the Val allele carriers and Met/Met homozygotes in the frequence of psychotic symptoms induced by methamphetamine (more frequent in Val carriers; P = 0.062; Chi-Square Test).

Conclusions

Further research involving haplotype analysis and other dopamine-related genetic polymorphisms in large populations is needed. More attention should also be paid to possible role of the Val158Met catechol-O-methyltransferase gene polymorphism in individual clinical subtypes of dependence on methamphetamine involving e.g. psychotic features or violence.

Type
Abstract
Information
European Psychiatry , Volume 27 , Issue S1: Abstracts of the 20th European Congress of Psychiatry , 2012 , pp. 1
Copyright
Copyright © European Psychiatric Association 2012
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