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P-1383 - Correlations Between Post-traumatic Spetrum Symptoms and Serum Neurosteroids Levels in Patients With Ptsd and Healthy Control Subjects

Published online by Cambridge University Press:  15 April 2020

C. Carmassi ,
M. Corsi ,
I. Pergentini ,
E. Massimetti ,
C. Socci ,
F. Belatti ,
I. Moroni ,
D. Marazziti  and
L. Dell’Osso
C. Carmassi
Affiliation:
Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologia, Pisa, Italy University of Pisa, Pisa, Italy
M. Corsi
Affiliation:
Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologia, Pisa, Italy University of Pisa, Pisa, Italy
I. Pergentini
Affiliation:
Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologia, Pisa, Italy University of Pisa, Pisa, Italy
E. Massimetti
Affiliation:
Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologia, Pisa, Italy University of Pisa, Pisa, Italy
C. Socci
Affiliation:
Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologia, Pisa, Italy University of Pisa, Pisa, Italy
F. Belatti
Affiliation:
Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologia, Pisa, Italy University of Pisa, Pisa, Italy
I. Moroni
Affiliation:
Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologia, Pisa, Italy University of Pisa, Pisa, Italy
D. Marazziti
Affiliation:
Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologia, Pisa, Italy University of Pisa, Pisa, Italy
L. Dell’Osso
Affiliation:
Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologia, Pisa, Italy University of Pisa, Pisa, Italy

Abstract

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Introduction

Many studies have explored the relationship between abnormalities of the hypothalamic-pituitary-adrenal (HPA) and anxiety disorders, nevertheless data on post-traumatic stress conditions are still controversial.

Objectives

To find a link between neurosteroids alterations and PTSD.

Aims

To explore cortisol and dehydroepiandrosterone sulfate (DHEA-S) serum levels in a sample of patients with post-traumatic stress disorder (PTSD), recruited from the general population, compared with a group of healthy control subjects.

Methods

We recruited 26 patients with PTSD (mean age: 43.69 ± 10.03 years), assessed by the SCID-I / P for the DSM-IV-TR diagnosis, and 26 healthy control subjects (mean age: 42.12 ± 10.39 years), without current or lifetime psychiatry disorders. The neurosteroid levels were measured in 10 ml of venous blood, between 9 and 10 am, at least 2 hours after awakening to minimize the physiological increase of cortisol in the morning. Patients and controls were assessed by Trauma and Loss Spectrum Self-Report [5] .

Results

Significantly lower cortisol levels, but not DHEA-S, were detected in patients with PTSD (c 2 = 15.97, p < .001) compared with control subjects. In addition, significant correlations emerged with domains of the TALS-SR.

Conclusions

Our results confirm the existence of a relationship between alterations in HPA axis and post-traumatic spectrum symptoms, although further studies are needed.

Type
Abstract
Information
European Psychiatry , Volume 27 , Issue S1: Abstracts of the 20th European Congress of Psychiatry , 2012 , pp. 1
Copyright
Copyright © European Psychiatric Association 2012

References

Dell’Osso, L., Carmassi, C., Rucci, P., et al.A Multidimensional Spectrum Approach to Post-traumatic Stress Disorder: Comparison Between the Structured Clinical Interview for Trauma and Loss Spectrum (sci-tals) and the Self-report Instrument (tals-sr). Comprehensive Psychiatry 5052009 48549010.1016/j.comppsych.2008.11.006CrossRefGoogle Scholar
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