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P-1270 - Cytokines Levels in Schizophrenia Patients and in Theirs First- Degree Biological Relatives

Published online by Cambridge University Press:  15 April 2020

I. Martinez-Gras ,
F. Garcia-Sanchez ,
C. Guaza ,
R. Rodriguez-Jimenez ,
E. Andres-Esteban ,
T. Palomo ,
G. Rubio  and
J. Borrel
I. Martinez-Gras
Affiliation:
Psychiatry, Complutense University, 12 Octubre Hospital, CIBERSAM, Madrid, Spain Mostoles Hospital, Madrid, Spain Functional and Systems Neurobiology Department, Cajal Institute (CSIC), Madrid, Spain Clinical Epidemiology Unit and CIBER Epidemiology and Public Health, Madrid, Spain Psychiatry, Complutense University, CIBERSAM, Madrid, Spain
F. Garcia-Sanchez
Affiliation:
Psychiatry, Complutense University, 12 Octubre Hospital, CIBERSAM, Madrid, Spain Mostoles Hospital, Madrid, Spain Functional and Systems Neurobiology Department, Cajal Institute (CSIC), Madrid, Spain Clinical Epidemiology Unit and CIBER Epidemiology and Public Health, Madrid, Spain Psychiatry, Complutense University, CIBERSAM, Madrid, Spain
C. Guaza
Affiliation:
Psychiatry, Complutense University, 12 Octubre Hospital, CIBERSAM, Madrid, Spain Mostoles Hospital, Madrid, Spain Functional and Systems Neurobiology Department, Cajal Institute (CSIC), Madrid, Spain Clinical Epidemiology Unit and CIBER Epidemiology and Public Health, Madrid, Spain Psychiatry, Complutense University, CIBERSAM, Madrid, Spain
R. Rodriguez-Jimenez
Affiliation:
Psychiatry, Complutense University, 12 Octubre Hospital, CIBERSAM, Madrid, Spain Mostoles Hospital, Madrid, Spain Functional and Systems Neurobiology Department, Cajal Institute (CSIC), Madrid, Spain Clinical Epidemiology Unit and CIBER Epidemiology and Public Health, Madrid, Spain Psychiatry, Complutense University, CIBERSAM, Madrid, Spain
E. Andres-Esteban
Affiliation:
Psychiatry, Complutense University, 12 Octubre Hospital, CIBERSAM, Madrid, Spain Mostoles Hospital, Madrid, Spain Functional and Systems Neurobiology Department, Cajal Institute (CSIC), Madrid, Spain Clinical Epidemiology Unit and CIBER Epidemiology and Public Health, Madrid, Spain Psychiatry, Complutense University, CIBERSAM, Madrid, Spain
T. Palomo
Affiliation:
Psychiatry, Complutense University, 12 Octubre Hospital, CIBERSAM, Madrid, Spain Mostoles Hospital, Madrid, Spain Functional and Systems Neurobiology Department, Cajal Institute (CSIC), Madrid, Spain Clinical Epidemiology Unit and CIBER Epidemiology and Public Health, Madrid, Spain Psychiatry, Complutense University, CIBERSAM, Madrid, Spain
G. Rubio
Affiliation:
Psychiatry, Complutense University, 12 Octubre Hospital, CIBERSAM, Madrid, Spain Mostoles Hospital, Madrid, Spain Functional and Systems Neurobiology Department, Cajal Institute (CSIC), Madrid, Spain Clinical Epidemiology Unit and CIBER Epidemiology and Public Health, Madrid, Spain Psychiatry, Complutense University, CIBERSAM, Madrid, Spain
J. Borrel
Affiliation:
Psychiatry, Complutense University, 12 Octubre Hospital, CIBERSAM, Madrid, Spain Mostoles Hospital, Madrid, Spain Functional and Systems Neurobiology Department, Cajal Institute (CSIC), Madrid, Spain Clinical Epidemiology Unit and CIBER Epidemiology and Public Health, Madrid, Spain Psychiatry, Complutense University, CIBERSAM, Madrid, Spain

Abstract

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Introduction

It is hypothesized that in the etiology of schizophrenia genetic and environmental factors are involved. Between the environmental events linked to the causation of this condition an inmune dysfunction has been described. First degree biological relatives of people with schizophrenia also have an incrased incidence of autoimmune diseases.

Objectives

The aim of this work was to examine the serum levels of proinflammatory cytokines (IL-1β, sIL-2R IL-6, IL-12p70, TNF-α and IFN-γ) as well as of anti-inflammatory cytokines (IL-4 and IL-10) in male patients with schizophrenia and in their first degree-biological relatives.

Methods

Blood samples were obtained from patients with a diagnosis of schizophrenia in a stable psychophatological condition (n = 36), first degree biological relatives of those patients and a healthy control group (n = 26). Serum interleukins were analyzed using a commercial ELISA preparation (Bender MedSystems). We used non-parametric test for statistical analysis.

Results

Patients with schizophrenia showed significantly higher serum levels of proinflammatory cytokines (sIL-2R, IL-6, TNF-α, IFN-γ and IL12-p70) and lower serum levels of the anti-inflammatory cytokine IL-4 than in the healthy control group. The unaffected first-degree relatives showed changes in proinflammatory cytokines (sIL-2R, IL-6 and TNF-α,) in the same way as the corresponding schizophrenia patients, but at a lower level than the healthy control group.

Conclusions

Ours findings suggest that sIL-2R, IL-6 and TNF-a may be biologic vulnerability markers for psychiatric disorders and also these alterations might have an hereditably pattern.

Type
Abstract
Information
European Psychiatry , Volume 27 , Issue S1: Abstracts of the 20th European Congress of Psychiatry , 2012 , pp. 1
Copyright
Copyright © European Psychiatric Association 2012
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