Hostname: page-component-586b7cd67f-r5fsc Total loading time: 0 Render date: 2024-11-30T15:30:28.900Z Has data issue: false hasContentIssue false

P-1126 - Sensitization Induced by Haloperidol and Olanzapine is Situationally Specific

Published online by Cambridge University Press:  15 April 2020

C. Zhang
Affiliation:
Shanghai Mental Health Center, Shanghai Jiao Tong University, School of Medicine, Shanghai, China
Y.R. Fang
Affiliation:
Shanghai Mental Health Center, Shanghai Jiao Tong University, School of Medicine, Shanghai, China
M. Li
Affiliation:
University of Nebraska, Lincoln, NE, USA

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Rationale

Repeated administration of haloperidol and olanzapine causes a progressively enhanced disruption of conditioned avoidance responding and a progressively enhanced inhibition of phencyclidine (PCP)-induced hyperlocomotion in rats. Both actions are thought to reflect the intrinsic antipsychotic activity.

Objective

The present study examined to the extent to which antipsychotic-induced sensitization in one model (e.g. conditioned avoidance response model) can be transferred or maintained in another (e.g. PCP hyperlocomotion model).

Methods: We first induced behavioral sensitization in one model through repeated administration of haloperidol or olanzapine to male Sprague-Dawley rats, then tested its expression in another model, and finally retested its expression back in the first model.

Results

Repeated haloperidol and olanzapine induced a robust behavioral sensitization in both models. Its expression was highly situational specific as it only manifested itself in the model in which it was being induced.

Conclusions

Based on these and other findings, we propose that three behavioral mechanisms regulate antipsychotic sensitization and its situational specificity:

  1. (1) Repeated antipsychotic treatment induces an unconditioned and nonassociative enhanced behavioral effect (i.e. sensitization) by progressively decreasing motivational salience of stimuli, an effect attributable to the direct pharmacological action of a drug;

  2. (2) Distinct contextual cues develop an association with unconditional drug effects via a Pavlovian conditioning process, thus acquiring the ability to elicit antipsychotic-like effects. This associative learning process may potentiate the sensitized behavioral response in an expected situation;

  3. (3) Contextual stimuli and interoceptive drug state also serve as occasion-setters to modulate the expression of sensitized responses.

Type
Abstract
Copyright
Copyright © European Psychiatric Association 2012
Submit a response

Comments

No Comments have been published for this article.