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P-1028 - the Parameters of Saccadic eye Movements in Individuals With Alzheimer's Disease Compared With Those of Healthy Subjects

Published online by Cambridge University Press:  15 April 2020

K. Pasgreta ,
E. Nowińska ,
J. Feit ,
N. Płaszczyca ,
P. Walecki  and
E. Gorzelańczyk
K. Pasgreta
Affiliation:
Department of Theoretical Basis of Bio-Medical Sciences and Medical Informatics, Collegium Medicum of Nicolaus Copernicus University in Torun, Warszawa, Poland
E. Nowińska
Affiliation:
Department of Theoretical Basis of Bio-Medical Sciences and Medical Informatics, Collegium Medicum of Nicolaus Copernicus University in Torun, Warszawa, Poland
J. Feit
Affiliation:
Department of Theoretical Basis of Bio-Medical Sciences and Medical Informatics, Collegium Medicum of Nicolaus Copernicus University in Torun, Warszawa, Poland
N. Płaszczyca
Affiliation:
Department of Theoretical Basis of Bio-Medical Sciences and Medical Informatics, Collegium Medicum of Nicolaus Copernicus University in Torun, Warszawa, Poland
P. Walecki
Affiliation:
Non-Public Health Care Center Sue Ryder Home, Collegium Medicum of Nicolaus Copernicus University in Torun, Bydgoszcz, Warszawa, Poland
E. Gorzelańczyk
Affiliation:
Faculty of Medicine, Jagiellonian University Medical College, Krakow, Warszawa, Poland Institute of Psychology, Polish Academy of Sciences, Warszawa, Poland

Abstract

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Introduction

There are abnormalities in eye movements in individuals with Alzheimer's disease, which are related to oculomotor frontal-subcortical circuit dysfunctions.

Objectives and aims

The aim of the study is to compare the parameters of saccadic eye movements in individuals with Alzheimer's disease with those in older adults without dementia.

Methods

31 individuals with mild and intermediate Alzheimer's dementia (MMSE > 13) (26 women, mean age 76.8 ± 6.41 and 5 men, mean age 79.1 ± 5.21) and 30 individuals without symptoms of dementia (matched for age) were examined.

The parameters of saccadic eye movements were measured with the use of Saccadometer Advanced. Two experiments were performed: Latency Trials (LAT) and Reflexive with Gap (RXG). Saccadic latency [ms], the reaction time [ms] and the number of executed saccades were measured.

Results:

LAT:

Statistically significant differences in the number of saccades (α = 0.05, p = 0.000024) and in average latency [ms] (α = 0.05, p = 0.039) between the individuals with AD and the healthy ones were found.

RXG:

Statistically significant differences were found in all the variables tested: number of executed saccades (α = 0.05, p = 0.0265), average latency [ms] (α = 0.05, p = 0.043) and average duration [ms] (α = 0.05, p = 0.000035) between persons from the control group and those from the experimental group.

Conclusions

It was found that the level of oculomotor efficiency in mild and intermediate Alzheimer's disease is significantly lower in relation to older people without dementia.

Type
Abstract
Information
European Psychiatry , Volume 27 , Issue S1: Abstracts of the 20th European Congress of Psychiatry , 2012 , pp. 1
Copyright
Copyright © European Psychiatric Association 2012
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