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P03-93 - Basal Metabolism In A Sample Of Patients Treated With Atypical Antipsychotics

Published online by Cambridge University Press:  17 April 2020

M. Mauri ,
C. Cargioli ,
G. Orsolini  and
A. Ciberti
M. Mauri
Affiliation:
Psychiatry, University of Pisa, Pisa, Italy
C. Cargioli
Affiliation:
Psychiatry, University of Pisa, Pisa, Italy
G. Orsolini
Affiliation:
Psychiatry, University of Pisa, Pisa, Italy
A. Ciberti
Affiliation:
Psychiatry, University of Pisa, Pisa, Italy

Abstract

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Introduction

Second generation antipsycotics (SGAs) represent an essential treatment for Psychotic Disorders. However SGAs cause weight gain and metabolic disorders with an unknown mechanism.

Objective

The aim of this study is to investigate whether weight gain may be caused by a reduction in resting energy expenditure (REE).

Methods

We recruited 34 pazients who received a clinical diagnosis of Bipolar Disorder I, Schizoaffective Disorder or Schizophrenia. Patients were in antipsychotic monotherapy (clozapine, olanzapine or aripiprazole). We measured REE by indirect calorimetry and we calculated theorical REE utilizing LARN and Harris-Benedict (H-B) equation.

Results

The difference between the average value of REE measured in patients (1295Kcal/die) and the average value of REE estimated by LARN and H-B equation (1719Kcal/die and 1741Kcal/die) was respectively 423Kcal/die and 445Kcal/die: both the differences resulted statistically significative (p< 0.01). This reduction of REE results in a weight gain of 1,7 kg in a month.

Conclusions

It is necessary to inform patients about the side effects of SGAs. Lifestyle counseling and pharmacological assistance, or switching to another antipsychotic are possible strategies.

Type
Psychotic disorders / Schizophrenia
Information
European Psychiatry , Volume 25 , Issue S1: 18th European Congress of Psychiatry. February 27, March 2, 2010 - Munich, Germany , 2010 , 25-E1203
Copyright
Copyright © European Psychiatric Association 2010
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