In our prospective study we compared 30 of patients with major depressive disorder, treated with cognitive- behavioral psychotherapy(CBT) and psycho pharmacotherapy (Group I) with 30 patients, with only psycho pharmacotherapy (group II) mean age 37,6 ± 10,8.

For 18 months there have been used Beck Depression inventory II (BDI-II), and Global Assessment of Functioning Scale, (GAF) on the beginning, at the end of treatment (after 12 months), and 6 months after treatment.

At the beginning of treatment in first group (patients under psychotherapy and psychopharmacotherapy) GAF shoved negative correlation in comparison with BDI (-0,62). In second group (patients cured with only psycho pharmacotherapy) GAF shoved negative correlation in comparison with, BDI (-0,66),. After one year of CBT and psycho pharmacotherapy mean value of improvements in first group were: BDI 37,4 ± 7,5, GAF 23,9, and GAF still highly correlated with BDI (-62). In second group mean value of improvements were: BDI 31,7 ± 10,8, GAF 13,2 ± 5,4 (significantly lower than in first group; p< 0,0001), but GAF still highly correlated with BDI (-69). Six months after psychotherapy all parameters in first group were significantly worsen:

In patients treated with combined cognitive-behavioral psychotherapy and pharmacotherapy there is a significant improvement of depression and functioning in relation to patients treated only with pharmacotherapy. Keywords: cogntive-behavioural psychotherapy, psychopharmacotherapy, anxiety, depression, hopelessness.