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P02-29 - Outpatient Utilization of Benzodiazepines in Serbia
Published online by Cambridge University Press: 17 April 2020
Abstract
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The increasing benzodiazepines utilization in Serbia has been described at the close of the XX century.
Benzodiazepines have addictive potential and are often a subject of abuse and misuse. Therefore, their use must be followed very closely in every society.
The aim of this study is to analyse the utilization of benzodiazepines in Serbia after the year of 2000.
This is a retrospective study (2000-2007) in which defined daily dose methodology is used. Drug use is expressed as number of defined daily doses/1000 inhabitants/day (DID). Tha data are obtained from the reports of the Medicines and Medical Devices Agency of Serbia. Statistics was performed using Pearson's linear correlation.
Total utilization of benzodiazepines significantly increased during the period of the study.
| Benzodiazepine | 2000 | 2001 | 2002 | 2003 | 2004 | 2005 | 2006 | 2007 | |r;p |
| Diazepam | 33.50 | 26.70 | 31.90 | 29.60 | 49.62 | 42.93 | 42.06 | 44 13 | r=0-729; |p<0.05* |
| Lorazepam | 2.40 | 3.50 | 4.60 | 8.60 | 11.82 | 11.64 | 14.83 | 22.60 | r=0.960; p<001** |
| Bromazepam | 2.70 | 4.60 | 6.50 | 8.20 | 33.46 | 27.82 | 20.14 | 28.05 | r=0.815; p<0.05* |
| Alprazolam | 1.90 | 2.10 | 3.80 | 4.20 | 10.25 | 7.42 | 13.26 | 11.97 | r=0,926; p<0,01 |
| Midazolam | 15.40 | 11.10 | 11.10 | 7.90 | 2.32 | 2.49 | 2.73 | 3.78 | r=-0,900; p<0.01** |
| Others | 0.00 | 0.00 | 1.10 | 1.35 | 8.64 | 2.15 | 5.23 | 6.64 | not available |
| Total | 55.90 | 48.00 | 59.00 | 59.85 | 109.42 | 94.45 | 98.15 | 117.17 | r=0.875; p<0.01** |
[Utilization of benzodiazepines in Serbia 2000-2007] The most prominent wass the increase of the use of lorazepam, bromazepam and diazepam.
There is a trend toward increasing benzodiazepines utilization in Serbia, which is in collision with the worldwide trends. Guidelines must be developed and implemented on all health care levels to promote more rational presribing of benzodiazepines.
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- Epidemiology
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- Copyright © European Psychiatric Association 2010
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