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P02-145 - The Neural Correlates of Visuo-spatial Working Memory in Patients with Amnestic Mild Cognitive Impairment

Published online by Cambridge University Press:  17 April 2020

K.K. Alichniewicz ,
H. Nebl ,
H.H. Klünemann  and
M.W. Greenlee
K.K. Alichniewicz
Affiliation:
Institute of Psychology, University of Regensburg, Regensburg, Germany
H. Nebl
Affiliation:
Institute of Psychology, University of Regensburg, Regensburg, Germany
H.H. Klünemann
Affiliation:
Department of Psychiatry, Psychosomatics and Psychotherapy, University of Regensburg, Regensburg, Germany
M.W. Greenlee
Affiliation:
Institute of Psychology, University of Regensburg, Regensburg, Germany

Abstract

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Objectives

The extent of working memory (WM) impairment has rarely been studied in patients with amnestic mild cognitive impairment (aMCI). The aim of the present study was to evaluate the cortical activation in these patients compared to healthy controls while performing a visuo-spatial WM task.

Methods

Functional magnetic resonance imaging (fMRI) with a 3-Tesla head scanner (Allegra, Siemens) was used to investigate the neural correlates of WM in 25 aMCI subjects and 12 matched controls while performing a visual-spatial n-back task (2-back). Both groups were pretested to ensure that all participants were able to understand and perform the task.

Results

In comparison to the healthy subjects, a random-effects analysis revealed that patients with aMCI showed less cortical activation especially in the left superior parietal cortex and left inferior frontal cortex. These areas are known to be involved in the control of attention and visuo-spatial WM.

Conclusions

Our findings suggest that attenuated cortical activation during working memory tasks may provide an early marker for aMCI.

Type
Neuroimaging
Information
European Psychiatry , Volume 25 , Issue S1: 18th European Congress of Psychiatry. February 27, March 2, 2010 - Munich, Germany , 2010 , 25-E759
Copyright
Copyright © European Psychiatric Association 2010
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