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P0180 - The plasma IL-18, MIP-1α, MCP-1, SDF-1 and rantes in patients with majior depression

Published online by Cambridge University Press:  16 April 2020

Y.D. Shen ,
P.L. Lu ,
X.Y. Hu ,
X.M. Tong  and
W. Chen
Y.D. Shen
Affiliation:
Department of Diagnostics, Clinical Medical School, Hangzhou Normal University, Hangzhou, China
P.L. Lu
Affiliation:
Department of Clinical Psychology and Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University College Medicine School, Hangzhou, China
X.Y. Hu
Affiliation:
Department of Clinical Psychology and Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University College Medicine School, Hangzhou, China
X.M. Tong
Affiliation:
The First Affiliate Hospital, Zhejiang University College Medicine School, Hangzhou, China
W. Chen
Affiliation:
Department of Clinical Psychology and Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University College Medicine School, Hangzhou, China

Abstract

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Background and Aims:

To investigate the plasma levels of IL-18, MIP-1α, MCP-1, SDF-1 and RANTES in major depression before and after treatment.

Method:

Twenty healthy volunteers and 40 patients with major depressive disorder (MDD) were involved in the current study. Depressed subjects had moderate or major depression according to the DSM-IV criteria. The HAMD scale was used to measure the efficacy after the 8-week treatment with fluoxetine hydrochloride. All subjects gave their written informed consents and were recruited from outpatients and inpatients of Sir Run Run Shaw Hospital between October 2004 and November 2005.The plasma levels of IL-18, MIP-1α, MCP-1, SDF-1 and RANTES in major depression were measured by ELISA before and after fluoxetine treatment.

Results:

HAMD score were significantly decreased after the treatment (P<0.001), there were seven cases score of after treatment <7,. At the time of admission, the plasma levels of IL-18, MCP-1, MIP-1α, SDF-1 and RANTES were significantly higher in the MDD than those in the healthy controls (P<0.001). In MDD, the cytokine values were significantly decreased after the treatment, including IL-18 (P=0.005), MCP-1 (P=0.001), MIP-1α (P<0.001, SDF-1 (P=0.004) and RANTES (P<0.001), but still significantly higher than those in the healthy controls (P<0.001).

Conclusions:

These findings suggest that major depression is accompanied by the immune activation, and the antidepressant treatments have anti-inflammatory effects. The remaining depression symptom after treatment may be related to the higher level of cytokines.

Type
Poster Session II: Depression
Information
European Psychiatry , Volume 23 , Issue S2: 16th AEP Congress - Abstract book - 16th AEP Congress , April 2008 , pp. S245
Copyright
Copyright © European Psychiatric Association 2008
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