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P0164 - Negative symptoms precede the onset of first episode psychosis in a prospective general population sample of adolescents

Published online by Cambridge University Press:  16 April 2020

P.H. Maki ,
J. Miettunen ,
M. Kaakinen ,
I. Moilanen ,
A. Taanila ,
P.B. Jones ,
G. Murray ,
M. Joukamaa ,
M. Heinimaa  and
J.M. Veijola
P.H. Maki
Affiliation:
Department of Psychiatry, University of Oulu, Oulu, Finland Department of Psychiatry, University Hospital of Oulu, Oulu, Finland
J. Miettunen
Affiliation:
Department of Psychiatry, University of Oulu, Oulu, Finland
M. Kaakinen
Affiliation:
Department of Public Health Science and General Practice, University of Oulu, Oulu, Finland
I. Moilanen
Affiliation:
Department of Psychiatry, University Hospital of Oulu, Oulu, Finland Clinic of Child Psychiatry, University of Oulu, Oulu, Finland
A. Taanila
Affiliation:
Department of Public Health Science and General Practice, University of Oulu, Oulu, Finland
P.B. Jones
Affiliation:
Department of Psychiatry, University of Cambridge, Cambridge, UK
G. Murray
Affiliation:
Department of Psychiatry, University of Cambridge, Cambridge, UK
M. Joukamaa
Affiliation:
Tampere School of Public Health, University of Tampere and Department of Psychiatry, Tampere University Hospital, Tampere, Finland
M. Heinimaa
Affiliation:
University of Turku, Turku, Finland
J.M. Veijola
Affiliation:
Department of Psychiatry, University of Oulu, Oulu, Finland The Academy of Finland, Helsinki, Finland

Abstract

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Background and Aims:

There are lacking prospective studies in general population of adolescents about symptoms predicting the onset of first episode psychosis.

Methods:

Members (N= 9,215) of the Northern Finland 1986 Birth Cohort, an unselected general population cohort, were invited to participate in a field survey during 2001, at ages of 15-16 years. The study included a 21-item PROD-screen questionnaire screening prodromal symptoms for psychosis for last six months (Heinimaa et al. 2003). PROD-screen included nine questions for positive and five questions for negative features. The Finnish Hospital Discharge Register was used to find out new cases of hospital treated mental disorders during 2002-2005.

Results:

Of the subjects 17 (0.3%) were treated due to first episode psychosis and 95 (1.5%) due to non-psychotic disorder during the follow-up period. Positive symptoms did not associate with the onset of psychosis, but negative symptoms did. 94% of subjects who got psychosis reported negative symptoms. Respective figure for those who were treated for non-psychotic disorder was 48%, and for those ‘healthy’ without psychiatric hospital treatment 46% (Fisher's exact test: psychosis vs. healthy p<0.001, psychosis vs. non-psychosis p<0.001, and non-psychosis vs. healthy p=0.61).

Conclusions:

This study may be the only one exploring prospectively in general population features predicting onset of first episode psychosis. The findings emphasize the importance of negative symptoms in the development of neuropsychiatric disorder of first episode psychosis (Weinberger 1995).

Acknowledgements:

The Academy of Finland, the Signe and Ane Gyllenberg Foundation, the Sigrid Juselius Foundation and the Thule Institute, Finland.

Type
Poster Session I: Schizophrenia and Psychosis
Information
European Psychiatry , Volume 23 , Issue S2: 16th AEP Congress - Abstract book - 16th AEP Congress , April 2008 , pp. S129
Copyright
Copyright © European Psychiatric Association 2008
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