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P01-62 - An Audit Comparing Suicidality Rates between Antidepressant Monotherapies Prescribed for Unipolar Depression

Published online by Cambridge University Press:  17 April 2020

M. Agius ,
J. Gardner ,
K. Liu  and
R. Zaman
M. Agius
Affiliation:
Psychiatry, Bedfordshire and Luton Partnership Trust, Luton, UK Psychiatry, Cambridge, UK
J. Gardner
Affiliation:
Clinical School, University of Cambridge, Cambridge, UK
K. Liu
Affiliation:
Clinical School, University of Cambridge, Cambridge, UK
R. Zaman
Affiliation:
Psychiatry, Cambridge, UK Psychiatry, Bedfordshire and Luton Partnership Trust, Bedford, UK

Abstract

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Background

It has been demonstrated that there are differences in efficacy and acceptability of commonly prescribed anti-depressants (Cipriani et al. 2009). Escitalopram, sertraline, venlafaxine and mirtazapine were the most effective.

Objectives

We wished to see whether our own data showed similar outcomes to the data from the metanalysis using decrease in suicidality as an outcome measure.

Aim

To compare the efficacy of anti-depressant monotherapies in patients with unipolar depression at Bedford Hospital, using suicidality (suicidal ideation and behaviour) as the outcome measure.

Method

We included all patients with unipolar depression on an antidepressant monotherapy in Bedford hospital in our analysis (145 in total). We examined the clinical notes for each patient to assess whether they demonstrated suicidality after being prescribed the antidepressant. This allowed us to calculate rates of suicidality for each antidepressant monotherapy.

Results

The prescription of sertraline was associated with the greatest reduction in suicidality, closely followed by citalopram.

Discussion

Our results support the findings of the meta-analysis. None of the patients on Escitalopram expressed suicidality, so a reduction in suicidality rates could not be demonstrated for this monotherapy.

Conclusion

This audit in a small group of patients suggests that sertraline is associated with the greatest reduction in suicidality compared to the other monotherapies prescribed.

Type
Affective disorders / Unipolar depression / Bipolar disorder
Information
European Psychiatry , Volume 25 , Issue S1: 18th European Congress of Psychiatry. February 27, March 2, 2010 - Munich, Germany , 2010 , 25-E281
Copyright
Copyright © European Psychiatric Association 2010

References

Cipriani, A., Furukawa, T.A., Salanti, G., Geddes, J.R., Higgins, J.P., Churchill, R., Watanabe, N., Nakagawa, A., Omori, I.M., McGuire, H., Tansella, M., Barbui, C. Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis. Lancet 2009Feb 28; 373(9665): 746–758CrossRefGoogle ScholarPubMed
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