Hostname: page-component-586b7cd67f-t8hqh Total loading time: 0 Render date: 2024-11-25T18:49:19.592Z Has data issue: false hasContentIssue false

P01-379 - Study on the Intestinal Endotoxemia in the Cell Apoptosis of Alzheimer Disease Rats

Published online by Cambridge University Press:  17 April 2020

F. Wang
Affiliation:
Shanxi Medical University, Taiyuan City, China
D. Han
Affiliation:
Shanxi Medical University, Taiyuan City, China

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Objective

The objective of the present study was to explore the intestinal endotoxemia (IETM) in the cell apoptosis of Alzheimer disease's rats which were established by D-galactose and aluminum trichloride (AlCl3).

Methods

Adult wistar rats were subjected to 90 days of intraperitoneal injection with D-galactose and AlCl3 to establish the Alzheimer disease's model. After the administration, the study and memory ability of the Alzheimer disease's rats were observed by Morris water maze; The level of Lipopolysaccharide (LPS) in the sera of Alzheimer disease's rats was determined by tachypleus amebocyte lysate method; The level of tumor necrosis factor-α (TNF-α) and interleukin-1 (IL-1) in the sera of Alzheimer disease's rats were determined by radioimmunity method; The apoptotic neuron was detected by TdT-mediated dUTP Nick End Labeling (TUNEL).

Results

Compared with the normal control, the level of LPS, TNF-αin the sera and PD in the brine of Alzheimer disease's rats were markedly increased (P< 0.01).

Conclusions

The level of LPS, TNF-αin the sera and PD in the brine of Alzheimer disease's rats were markedly increased, IETM maybe an important reason of the apoptotic in Alzheimer disease.

Type
Dementia / Gerontopshychiatry
Copyright
Copyright © European Psychiatric Association 2010
Submit a response

Comments

No Comments have been published for this article.