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P01-379 - Study on the Intestinal Endotoxemia in the Cell Apoptosis of Alzheimer Disease Rats

Published online by Cambridge University Press:  17 April 2020

F. Wang
Affiliation:
Shanxi Medical University, Taiyuan City, China
D. Han
Affiliation:
Shanxi Medical University, Taiyuan City, China

Abstract

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Objective

The objective of the present study was to explore the intestinal endotoxemia (IETM) in the cell apoptosis of Alzheimer disease's rats which were established by D-galactose and aluminum trichloride (AlCl3).

Methods

Adult wistar rats were subjected to 90 days of intraperitoneal injection with D-galactose and AlCl3 to establish the Alzheimer disease's model. After the administration, the study and memory ability of the Alzheimer disease's rats were observed by Morris water maze; The level of Lipopolysaccharide (LPS) in the sera of Alzheimer disease's rats was determined by tachypleus amebocyte lysate method; The level of tumor necrosis factor-α (TNF-α) and interleukin-1 (IL-1) in the sera of Alzheimer disease's rats were determined by radioimmunity method; The apoptotic neuron was detected by TdT-mediated dUTP Nick End Labeling (TUNEL).

Results

Compared with the normal control, the level of LPS, TNF-αin the sera and PD in the brine of Alzheimer disease's rats were markedly increased (P< 0.01).

Conclusions

The level of LPS, TNF-αin the sera and PD in the brine of Alzheimer disease's rats were markedly increased, IETM maybe an important reason of the apoptotic in Alzheimer disease.

Type
Dementia / Gerontopshychiatry
Copyright
Copyright © European Psychiatric Association 2010
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