The gol of the project is improve the management of depression in the primary care setting. In first time we meet the primary care physicians for a consensus conference on depression, clinical case and the treatment recommendations in the primary care setting. In second time we sent the guidelines to all contracted primary care physicians and specialists via the practitioner newsletter. The guidelines were developed in conjunction with the SIMG (società Italiana di Medicina Generale), and the S.I.P. (Società Italiana di Psichiatria) and Department of Mental Health. The guidelines included treatment of major depressive disorder. In the third time the health plan continues to periodically update the guidelines and provide them to all practitioners.