We aimed to assess the quality of life and psychosocial factor of patients presenting with medically unexplained symptom at a private general practice in Lagos Nigeria.

A total of 150 subjects presenting with unexplained symptoms out of 1,450 G.P consulted had world health organization Quality of life (Brif) questionnaire obtained. The Quality of life score and social factors were compared with patients without unexplained symptoms.

Majority of patients with unexplained symptom were female, with mean age of 42(±8) and unemployed. Among the patients, 80% had unexplained pain symptoms. Quality of life was poor in subject with unexplained symptoms and was significantly different in comparison with those without medically unexplained symptoms.

General practice patients with medically unexplained symptom had remarkably poorer quality of life and associated sociodemographic factors include age, sex and unemployment. Early identification and prompt treatment should be encouraged.