No CrossRef data available.
Article contents
P01-256 - Long-term influence of rats with newborn fluoxetine exposure at different period
Published online by Cambridge University Press: 17 April 2020
Abstract
Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Objective
To evaluate newborn fluoxetine exposure at different period on development and behavior of adult rats.
Methods
Male rat pups were randomized to be treated once daily with fluoxetine(s.c.) or saline(s.c.) during postnatal day 1∼7 and postnatal day 8∼21. Recorded the body weight. Starting at 90 days of age, all rats were tested with several experimental facilities, including open field test, elevated-plus maze, novelty- suppressed feeding test and forced swim test.
Results
:
1 Weight gain of rats with fluoxetine exposure during postnatal day 1∼7 were lower than controls (P<0.05).
2 Exploratory behavior decreased and depression anxiety behavior increased in adult rats with neonatal fluoxetine exposure (P<0.05), and more severe with postnatal day 1∼7 exposure (P<0.05).
Conclusions
Newborn fluoxetine exposure may result badness weight gain and depression anxiety behavior in adult rats, and the earlier exposure may accompany the larger risk.
- Type
- Child and adolescent psychiatry
- Information
- Copyright
- Copyright © European Psychiatric Association 2010
You have
Access
Comments
No Comments have been published for this article.