Hostname: page-component-78c5997874-fbnjt Total loading time: 0 Render date: 2024-11-17T05:16:56.420Z Has data issue: false hasContentIssue false
  • English
  • Français

P0075 - Delay of left hemisphere in processing information in schizophrenia?

Published online by Cambridge University Press:  16 April 2020

M. Baiano ,
S. Savazzi ,
S. Sponda ,
C. Perlini ,
G. Rambaldelli ,
M. Bellani ,
M. Tansella ,
C.A. Marzi  and
P. Brambilla
M. Baiano
Affiliation:
Department of Pathology and Clinical and Experimental Medicine, Section of Psychiatry, University of Udine, Udine, Italy
S. Savazzi
Affiliation:
Department of Neurological and Vision Sciencs, Section of Physiology, University of Verona, Verona, Italy
S. Sponda
Affiliation:
Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
C. Perlini
Affiliation:
Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
G. Rambaldelli
Affiliation:
Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
M. Bellani
Affiliation:
Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
M. Tansella
Affiliation:
Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
C.A. Marzi
Affiliation:
Department of Neurological and Vision Sciencs, Section of Physiology, University of Verona, Verona, Italy
P. Brambilla
Affiliation:
Department of Pathology and Clinical and Experimental Medicine, Section of Psychiatry, University of Udine, Udine, Italy

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Background:

Several neuroimaging studies have shown impaired microstructural integrity of corpus callosum in schizophrenia, which may support inter-hemispheric misconnection. However, functional connectivity has rarely been investigated in schizophrenia.

Objectives:

To explore inter-hemispheric communication in a sample of patients with schizophrenia in comparison to healthy controls.

Methods:

Twenty-five patients with schizophrenia and forty-one healthy controls were studied. Subjects were asked to press a key with the index-finger of their right or the left hand as quickly as possible following appearance of either a single or a double stimulus. Two measures were calculated: the difference between manual reaction times (RT) after the presentation of single stimuli to the ipsilateral (uncrossed response) or contralateral (crossed response) visual hemifield (the so-called Poffenberger Paradigm), as a measure of interhemispheric transfer time (ITT), and the difference between double and single stimuli (the Redundant Target Effect, RTE), as a measure of interhemispheric integration.

Results:

Overall, patients with schizophrenia responded faster with the left than with the right hand (Paired sample t-test p=0.019). Importantly, in schizophrenics there was no group difference in ITT but there was a significantly enhanced RTE .

Conclusions:

The slower RT for right hand in schizophrenics possibly reflects a general delay of the left cerebral hemisphere in visuomotor RT. Moreover, the enhanced RTE suggests an impairment of interhemispheric integration in schizophrenia.

Type
Poster Session I: Schizophrenia and Psychosis
Information
European Psychiatry , Volume 23 , Issue S2: 16th AEP Congress - Abstract book - 16th AEP Congress , April 2008 , pp. S102 - S103
Copyright
Copyright © European Psychiatric Association 2008
Submit a response

Comments

No Comments have been published for this article.