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P0062 - Influence of maternal alcoholism on vessels of human embryonic brain

Published online by Cambridge University Press:  16 April 2020

A.V. Solonsky
A.V. Solonsky*
Affiliation:
Pathomorphology Laboratory, Mental Health Research Institute, Tomsk, Russia

Abstract

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Embryos of week 7-12 of the development were studied, which were obtained during conducting of operation of abortion.

Totally 43 embryos have been obtained: 23 – from alcoholic female patients and 20 –healthy women (control). In all cases II stage of alcoholism was diagnosed (F10.201; F10.202). For computer morphometry there have been used brain sections 1-1,5 mcm, coloured with methylene blue. For statistic data program Statistica 6.0 was used.

Results:

One of these peculiarities is considerable and reliable predominance of total square of the vessels in control group above that in the trial one (p<0,001). Analysis of the square of the vessels in both groups according to time parameters (weeks development) has allowed to establish that square occupied by vessels in the control group, is more at week 10 and 12 these differences are not reliable and at week 11 value of the square in control group significantly exceeds the trial one, being reliably (p<0,001).

According to terms of the development of the embryos it was allowed to establish that for 7-12 weeks significant differences are observed in indices of the mean vessels square between trial and control groups at week 11 – in control the square is more in average by 13,91 mcm2 (р<0,05).

Conclusion:

Alcoholization of the maternal organism in the period of the pregnancy renders significant impact on the dynamic of the development of blood vessels of the embryonic human brain, what is expressed, primarily, in delay of the development of embryonic capillaries of the growing brain.

Type
Poster Session III: Alcoholism And Addiction
Information
European Psychiatry , Volume 23 , Issue S2: 16th AEP Congress - Abstract book - 16th AEP Congress , April 2008 , pp. S321
Copyright
Copyright © European Psychiatric Association 2008
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