Considerable number of latent drug users is testified by increase of lethal outcomes because of drug overdosing. We have analyzed lethal outcomes when cause of death was opioid overdosing. We have considered 98 cases among them in 86 cases – men died, in 12 - women. Lethal outcome of drug overdose has occurred at the age of 20,6±1,12 years. Diagnosis of somatic pathology in opioid addicts shows clinical-morphological consistence in chronic hepatitis of viral and toxic etiology (77,5%). Identification of impairments of cardiovascular and excretory systems does not reveal similar consistence: renal impairments are clinically diagnosed in 7,2% of cases, disorders of cardiovascular system in clinical picture of opioid addiction are found in not more than 10% of patients. As a rule, possibilities of early and quick development of dystrophic (fatty) and sclerotic processes in cardiac muscle and coronary vessels as well as epithelium of canals of kidneys that during a morphological diagnosis are revealed in 41,4% and 53,4% of cases, respectively, are not taken into account. Sclerotic alterations and fatty dystrophy of organs as well as another somatic pathology revealed lifetime and during autopsy testify to early disturbances of metabolic processes in chronic opioid intoxication characterized by progression, formed for short time (3,6 years) and at young age (22,5±3,1 years).