Depression is old as a humanity, it s the disease that has been described in the early days of medical history. Depression is the most common disorder nowadays. Sometimes alcoholism and narcomania can mask depression. The aim of our work was to find out about the efficiency of Trazodon in treating depressive disorder with alcoholics who were treated at the department for alcohol addiction in Special Psychiatric Hospital Gornja Toponica in the period May-October 2007 (18 patients). For our research we used Beck's scale (Beck and associates) to evaluate the degree of depression. The research lasted for six weeks (average length of hospitalization). After the first week of treatment there was a progress concerning sleeping and reduction of anxiety. The anti-depressing score was evident already after two weeks, there also has been a remarkable dropping of the amount on Beck's scale for evaluation of depression. Throughout the research of the efficiency with depression symptomatology, the dayly dosage for alcoholics wasn't over the 200 mg (mostly 150 mg). During 6 weeks of clinical study Trazodon successfully reduced the symptoms of depression in alcohol addicts and after hospitalized treatment significantly helped to maintain abstinency. It was equaly used on young and elderly patients and there haven t been notices of any negative effects.