Hostname: page-component-586b7cd67f-dsjbd Total loading time: 0 Render date: 2024-11-23T17:28:11.517Z Has data issue: false hasContentIssue false

P0013 - Modafinil for cocaine addiction: Multi-site clinical trial

Published online by Cambridge University Press:  16 April 2020

A.M. Elkashef
Affiliation:
Dpmc, Nida, Nih, Bethesda, MD, USA
A. Anderson
Affiliation:
Dpmc, Nida, Nih, Bethesda, MD, USA
S.H. Li
Affiliation:
Dpmc, Nida, Nih, Bethesda, MD, USA
R. Kahn
Affiliation:
Dpmc, Nida, Nih, Bethesda, MD, USA
D. Ciraulo
Affiliation:
Psychiatry Department, Boston University, Boston, MA, USA
M. Reid
Affiliation:
Psychiatry Department, New York University, New York, NY, USA
J. Roache
Affiliation:
Psychiatry Department, START Center, San Antonio, TX, USA
H. Urschel
Affiliation:
Psychiatry Department, Reserach Across America, Dallas, TX, USA
E. Somoza
Affiliation:
Psychiatry Department, Cincinnati ARC, Cincinnati, OH, USA
I. Salloum
Affiliation:
Psychiatry Department, Western Psychiatry Institute, Pittsburgh, PA, USA

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Background and Aims:

Modafinil was tested for efficacy in facilitating abstinence in cocaine-dependent patients, compared to placebo.

Methods:

This is a double-blind placebo-controlled study, with 12 weeks of treatment and a 4-week follow-up. 210 treatment-seekers with DSM-IV diagnosis of cocaine dependence consented and enrolled. 72 participants were randomized to placebo, 69 to modafinil 200mg, and 69 to modafinil 400mg, taken once daily on awakening. Participants attended the clinic three times per week for assessments and urine drug screens, and had one hour of individual psychotherapy once per week. The primary outcome was the increase in weekly percentage of non-use days. Secondary outcomes included: decrease in the weekly median log of urine benzoylecgonine, subgroup analyses of balancing factors and co-morbid conditions, self-report of alcohol use, addiction severity, craving, and risk behaviors for HIV.

Results:

125 participants completed 12 weeks of treatment (60%). The GEE regression analysis showed that for the total sample, the difference between modafinil groups and placebo in the weekly percentage of cocaine non-use days over the 12-week treatment period was not statistically significant (p=0.95). A post-hoc analysis showed a significant effect for modafinil, only in the subgroup of cocaine patients without alcohol dependence. Modafinil 200mg also showed significant effects of an increase in the total number of consecutive non-use days for cocaine (p=0.02), and a reduction in craving (p=0.04).

Conclusions:

These data suggest that modafinil, in combination with individual behavioral therapy, was effective for increasing cocaine non-use days in participants without co-morbid alcohol dependence, and in reducing craving.

Type
Poster Session III: Alcoholism And Addiction
Copyright
Copyright © European Psychiatric Association 2008
Submit a response

Comments

No Comments have been published for this article.