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P0002 - The presence of childhood sexual abuse a risk for antithyroid antibodies posivity in the postpartum depression. A preliminary study

Published online by Cambridge University Press:  16 April 2020

A. Plaza ,
L.L. Garcia-Esteve ,
P. Navarro ,
C. Ascaso ,
M. Piñeiro ,
R. Martin-Santos  and
E. Gelabert
A. Plaza
Affiliation:
Unit of Perinatal Psychiatry and Gender Research (UPPiRG), Hospital Clínic Universitari de Barcelona, Barcelona, Spain
L.L. Garcia-Esteve
Affiliation:
Unit of Perinatal Psychiatry and Gender Research (UPPiRG), Hospital Clínic Universitari de Barcelona, Barcelona, Spain
P. Navarro
Affiliation:
Unit of Perinatal Psychiatry and Gender Research (UPPiRG), Hospital Clínic Universitari de Barcelona, Barcelona, Spain
C. Ascaso
Affiliation:
Department of Public Health of The University of Barcelona, Barcelona, Spain Institut D'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain
M. Piñeiro
Affiliation:
Department of Public Health of The University of Barcelona, Barcelona, Spain
R. Martin-Santos
Affiliation:
Drug Abuse and Psychiatric Department, Hospital Del Mar, Barcelona, Spain EPharmacology Research Unit, Institut Municipal D'Investigació Mèdica (IMIM), Barcelona, Spain
E. Gelabert
Affiliation:
Unit of Perinatal Psychiatry and Gender Research (UPPiRG), Hospital Clínic Universitari de Barcelona, Barcelona, Spain EPharmacology Research Unit, Institut Municipal D'Investigació Mèdica (IMIM), Barcelona, Spain

Abstract

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Objective:

To examine whether the postpartum depression (PPD) subgroup with positive antithyroid antibodies (Ab+) compared with the PPD subgroup without positive presence of Ab (Ab -) have a different psycho-social and psychopathological characteristics.

Methods:

One hundred three (N=103) patients with PPD according with DSM-IV criteria were included. Autoimmune status of the thyroid (Thyroperoxidasa antibodies, Thyroglobulin antibodies), severity of depression and anxiety (EPDS and 21-item Hamilton and STAI-S scales), psychosocial variables (Early Trauma Inventory, Saint Paul Ramsey Questionnaire, Marital Adjustment Test) were assessed joint with other several demographics and reproductive variables.

Results:

The presence of childhood sexual abuse in PPD women increase the probability of Ab(+) (OR= 2,528 ; 95% CI =1,00-6,39). The levels of Thyroid peroxidase antibodies (TPOAb) titers have a strongly correlation (p<0,000) with the levels of the Early Trauma Inventory.

Conclusions:

The results of our study give a link between early stress, the immune system, and postpartum depression.The implication of the immunitary system in the etiopathogenesis of the PPD through the long lasting sensitization of the inflammatory response system and the endocrine system in front to stress behind the CNS and their transmisors and receptors activation is discussed.

Type
Poster Session I: Stress
Information
European Psychiatry , Volume 23 , Issue S2: 16th AEP Congress - Abstract book - 16th AEP Congress , April 2008 , pp. S81
Copyright
Copyright © European Psychiatric Association 2008
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