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Orally disintegrating olanzapine induces less weight gain in adolescents than standard oral tablets

Published online by Cambridge University Press:  30 August 2007

Marc-antoine Crocq ,
Marie-Sa Guillon ,
Paul Ernest Bailey  and
Dominique Provost
Marc-antoine Crocq*
Affiliation:
Centre Hospitalier, Service de Psychiatrie de l'Adolescent, BP29, 68250Rouffach, France
Marie-Sa Guillon
Affiliation:
Centre Hospitalier, Service de Psychiatrie de l'Adolescent, BP29, 68250Rouffach, France
Paul Ernest Bailey
Affiliation:
Centre Hospitalier, Service de Psychiatrie de l'Adolescent, BP29, 68250Rouffach, France
Dominique Provost
Affiliation:
Centre Hospitalier, Service de Psychiatrie de l'Adolescent, BP29, 68250Rouffach, France
*
∗Corresponding author. Tel.: +33 6 62 33 56 84; fax: +33 3 89 78 72 00. E-mail address: [email protected] (M.-A. Crocq).
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Abstract

We compared the changes in weight (kg) and body mass index (BMI) (kg/m2) in 52 hospitalized adolescents between baseline and after 12 weeks of monotherapy with either (i) olanzapine (OLZ) orally disintegrating tablets (ODT) (N = 16; 16.6 mg/day ± 4.4 [SD]), or (ii) OLZ standard oral tablets (SOT) (N = 10; 18.0 mg/day ± 4.2), or (iii) risperidone (N = 26; 2.8 mg/day ± 1.2). Significantly greater increases in mean weight and BMI were observed in the patients treated with OLZ SOT (8.9 ± 5.1 [SD] kg; 1.9 ± 0.6 kg/m2, respectively) than in those with ODT (3.0 ± 2.1 kg; 1.1 ± 0.8 kg/m2). Similarly, OLZ ODT treatment was associated with significantly greater increases in weight and BMI than risperidone (1.0 ± 1.8 kg; 0.4 ± 0.7 kg/m2). These findings suggest that adolescents gain less weight with OLZ ODT than OLZ SOT, possibly because the former formulation shortens the time of interaction with digestive serotonin receptors mediating satiety.

Keywords

OlanzapineOrally disintegrating tabletsWeight gainBMIAdolescents
Type
Case report
Information
European Psychiatry , Volume 22 , Issue 7 , October 2007 , pp. 453 - 454
Copyright
Copyright © Elsevier Masson SAS 2007

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References

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