To study the effectiveness of antidepressant sevpram (citalopram) and its combination with galavit (imunomodulyator) on a background of standard pharmacotherapy in heroin addiction. To evaluate the immune status of the following methods:

– evaluation of lymphocytes (CD4), (CD8) with monoclonal antibodies in cytotoxicity assay;

– determination of serum immunoglobulin classes A, M, G performed by turbidimetric analysis;

– the concentration of the CIK (circulating immunnokompleks) was determined by precipitation with polyethylene glycol.

Patients of the 1st group was administered into the sevpram 10 mg/day in combination with galavit (25 mg daily); group 2 – only the standard therapy (ST).

As a result of the treatment in the first group showed an increase of 34.8%) the number of immunoglobulin A, which however does not reach the level of healthy people and reducing the number of circulating complexes by 13.8%, which also indicates the normalization of this index. The first group – a significant improvement of immunological parameters increase of 3 indicators (CD4, CD8, CD4/CD8) and a decrease in the CIK. Analysis of changes in indicators Hamilton Rating Scale for Depression, also notes a reduction in the symptoms scores.

The authors have not supplied their declaration of competing interest.