Reports about the course of pregnancy in women treated with atypical antipsychotics are rare.

Case report of a woman who presented an overdose with olanzapine during pregnancy. Results : Ms. A. was a 21-year-old Caucasian woman with a 3-years history of schizophrenia according to the DSM-IV criteria. She was successfully treated with olanzapine during 2 years before the onset of pregnancy. While Ms. A was stabilized with olanzapine treatment, she became pregnant. Olanzapine treatment was switched to haloperidol 10mg/day at week 2 of gestation. However, she stopped haloperidol after 15 days. While she stopped antipsychotic treatment, her symptoms increased, particularly irritability, anxiety, attentional disorders and dizorganized behaviors. At week 16 of gestation, feeling psychological distress, she took 112.5 mg of olanzapine of her own. Olanzapine was started again after giving her informed consent. She showed significant symptomatic improvement and received olanzapine 7.5mg/day from week 16 of gestation until delivery. She had no side effects from olanzapine treatment, in particular blood sugar levels were normal, from 4.6 to 5.4 mmol/l. Her weight was 60 kg (BMI=20) before the onset of pregnancy, 72 kg at the delivery. At week 37, a healthy baby girl was delivered. The baby weighed 3.415 kg. Her height was 52 cm. Her Apgar scores were 7 at 1 minute and 7 at 5 minutes. Ms. A did well and was discharged 12 days after delivery to improve her psychosocial education. However, more studies are needed to ascertain the safety of olanzapine during pregnancy.