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Obstetric complications in patients with schizophrenia and their unaffected siblings

Published online by Cambridge University Press:  16 April 2020

M. Walshe ,
C. McDonald ,
M. Taylor ,
J. Zhao ,
P. Sham ,
A. Grech ,
K. Schulze ,
E. Bramon  and
R.M. Murray
M. Walshe
Affiliation:
Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, London, United Kingdom
C. McDonald*
Affiliation:
Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, London, United Kingdom
M. Taylor
Affiliation:
Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, London, United Kingdom
J. Zhao
Affiliation:
Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, London, United Kingdom
P. Sham
Affiliation:
Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, London, United Kingdom
A. Grech
Affiliation:
Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, London, United Kingdom
K. Schulze
Affiliation:
Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, London, United Kingdom
E. Bramon
Affiliation:
Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, London, United Kingdom
R.M. Murray
Affiliation:
Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, London, United Kingdom
*
*Corresponding author. E-mail address: [email protected] (C. McDonald).
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Abstract

Objective

We sought to explore whether obstetric complications (OCs) are more likely to occur in the presence of familial/genetic susceptibility for schizophrenia or whether they themselves represent an independent environmental risk factor for schizophrenia.

Methods

The presence of OCs was assessed through maternal interview on 216 subjects, comprising 36 patients with schizophrenia from multiply affected families, 38 of their unaffected siblings, 31 schizophrenic patients with no family history of psychosis, 51 of their unaffected siblings and 60 normal comparison subjects. We examined the familiality of OCs and whether OCs were commoner in the patient and sibling groups than in the control group.

Results

OCs tended to cluster within families, especially in multiply affected families. Patients with schizophrenia, especially those from multiply affected families, had a significantly higher rate of OCs compared to normal comparison subjects, but there was no evidence for an elevated rate of OCs in unaffected siblings.

Conclusion

Our data provides little evidence for a link between OCs and genetic susceptibility to schizophrenia. If high rates of OCs are related to schizophrenia genes, this relationship is weak and will only be detected by very large sample sizes.

Keywords

SchizophreniaObstetric complicationsSiblingsFamily study
Type
Original article
Information
European Psychiatry , Volume 20 , Issue 1 , January 2005 , pp. 28 - 34
Copyright
Copyright © Elsevier SAS 2005

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References

American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders. Washington: American Psychiatric Press; 1987. (DC)Google Scholar
Bennesden, BAdverse pregnancy outcome in schizophrenic women: occurrence of risk factors. Schizophr Res 1998;22:1–26.Google Scholar
Blondel, B, Dutilh, P, Delour, M, Uzan, SPoor antenatal care and pregnancy outcome. Eur J Obstet Gynecol Reprod Biol 1993;50:191–196.10.1016/0028-2243(93)90200-VCrossRefGoogle ScholarPubMed
Buka, SL, Goldstein, JM, Seidman, LJ, Tsuang, MTMaternal recall of pregnancy history: accuracy and bias in schizophrenia research. Schizophr Bull 2000;26:335–350.CrossRefGoogle ScholarPubMed
Cannon, M, Jones, PB, Murray, RMObstetric complications and schizophrenia: historical and meta-analytic review. Am J Psychiat 2002;159:1080–1092.CrossRefGoogle ScholarPubMed
Cannon, TD, Rosso, IM, Hollister, JM, Bearden, CE, Sanchez, LE, Hadley, TA prospective cohort study of genetic and perinatal influences in the etiology of schizophrenia. Schizophr Bull 2000;26:351–366.CrossRefGoogle ScholarPubMed
Cannon, TD, Van Erp, TGM, Rosso, IM, Huttunen, M, Lonnqvist, J, Pirkola, Tet al.Fetal hypoxia and structural brain abnormalities in schizophrenic patients, their siblings, and controls. Arch Gen Psychiatr 2002;59:35–41.CrossRefGoogle ScholarPubMed
Cantor-Graae, E, Ismail, B, McNeil, TFAre neurological abnormalities in schizophrenic patients and their siblings the result of perinatal trauma?. Acta Psychiatr Scand 2000;101:142–147.CrossRefGoogle ScholarPubMed
Cantor-Graae, E, Cardenal, S, Ismail, B, McNeil, TFRecall of obstetric events by mothers of schizophrenic patients. Psychol Med 1998;28:1239–1243.10.1017/S0033291798006953CrossRefGoogle ScholarPubMed
Crawford, TJ, Sharma, T, Puri, BK, Murray, RM, Berridge, DM, Lewis, SWSaccadic eye movements in families multiply affected with schizophrenia: the Maudsley Family Study. Am J Psychiat 1998;155:1703–1710.CrossRefGoogle ScholarPubMed
DeLisi, LE, Goldin, LR, Maxwell, EM, Kazuba, DM, Gershon, ESClinical features of illness in siblings with schizophrenia or schizoaffective disorder. Arch Gen Psychiatr 1987;44:891–896.CrossRefGoogle ScholarPubMed
Eagles, JM, Gibson, I, Bremner, MH, Clunie, F, Ebmeier, KP, Smith, NCObstetric complications in DSM-III schizophrenics and their siblings. Lance 1990;335:1139–1141.CrossRefGoogle ScholarPubMed
Endicott, J, Andreasen, NC, Spitzer, RLFamily history research diagnostic criteri. New York: New York State Psychiatric Institute, Biometrics Research Division; 1975.Google Scholar
Faraone, SV, Seidman, LJ, Kremen, WS, Toomey, R, Pepple, JR, Tsuang, MTNeuropsychologic functioning among the nonpsychotic relatives of schizophrenic patients: the effect of genetic loading. Biol Psychiatr 2000;48:120–126.CrossRefGoogle ScholarPubMed
Filippi, V, Ronsmans, C, Gandaho, T, Graham, W, Alihonou, E, Santos, PWomen’s reports of severe (near-miss) obstetric complications in Benin. Stud Fam Plann 2000;31:309–324.CrossRefGoogle ScholarPubMed
Frangou, S, Sharma, T, Sigmudsson, T, Barta, Pet al.The Maudsley Family Study 4: normal planum temporale asymmetry in familial schizophrenia: a volumetric MRI study. Br J Psychiatr 1997;170:328–333.10.1192/bjp.170.4.328CrossRefGoogle ScholarPubMed
Franzek, E, Stober, GMaternal infectious diseases during pregnancy and obstetric complications in the etiology of distinct subtypes of schizophrenia: further evidence from maternal hospital records. Eur Psychiatr 1995;10:326–330.CrossRefGoogle ScholarPubMed
Geddes, JR, Lawrie, SMObstetric complications and schizophrenia: a meta-analysis. Br J Psychiatr 1995;167:786–793.CrossRefGoogle ScholarPubMed
Griffiths, TD, Sigmundsson, T, Takei, N, Rowe, D, Murray, RMNeurological abnormalities in familial and sporadic schizophrenia. Brai 1998;121:191–203.CrossRefGoogle ScholarPubMed
Gunther-Genta, F, Bovet, P, Hohlfeld, PObstetric complications and schizophrenia. A case–control study. Br J Psychiatr 1994;164:165–170.CrossRefGoogle ScholarPubMed
H.M.S.O Office of population censuses and surveys, standard occupational classification. London: HMSO; 1991.Google Scholar
Heun, R, Maier, WThe role of obstetric complications in schizophrenia. J Nerv Ment Dis 1993;181:220–226.CrossRefGoogle Scholar
Howard, LM, Goss, C, Leese, M, Thornicroft, GMedical outcome of pregnancy in women with psychotic disorders and their infants in the first year after birth. Br J Psychiatr 2003;182:63–67.CrossRefGoogle ScholarPubMed
Kinney, DK, Levy, DL, Yurgelun-Todd, DA, Medoff, D, LaJonchere, CM, Radford-Paregol, MSeason of birth and obstetrical complications in schizophrenics. J Psychiatr Res 1994;28:499–509.CrossRefGoogle ScholarPubMed
Lewis, SW, Owen, MJ, Murray, RMObstetric complications and schizophrenia: methodology and mechanisms. Schulz, SC, Tamminga, CASchizophrenia: scientific progres. New York (NY) US: Oxford University Press; 1989. 56–68.Google Scholar
Liu, S, Shi Wu, W, Demissie, K, Marcoux, S, Kramer, MSMaternal asthma and pregnancy outcomes: a retrospective cohort study. Am J .Obstet Gynecol 2001;184:90–96.CrossRefGoogle ScholarPubMed
Loffredo, CA, Wilson, PD, Ferencz, CMaternal diabetes: an independent risk factor for major cardiovascular malformations with increased mortality of affected infants. Teratolog 2001;64:98–106.CrossRefGoogle ScholarPubMed
Marcelis, M, Van Os, J, Sham, P, Jones, P, Gilvarry, C, Cannon, Met al.Obstetric complications and familial morbid risk of psychiatric disorders. Am J Med Genet 1998;81:29–36.3.0.CO;2-I>CrossRefGoogle ScholarPubMed
McDonald, C, Grech, A, Toulopoulou, T, Schulze, K, Chapple, B, Sham, Pet al.Brain volumes in familial and non-familial schizophrenic probands and their unaffected relatives. Am J Med Genet 2002;114:616–625.CrossRefGoogle ScholarPubMed
McIntosh, AM, Holmes, S, Gleeson, S, Burns, JK, Hodges, AK, Byrne, MMet al.Maternal recall bias, obstetric history and schizophrenia. Br J Psychiatr 2002;181:520–525.CrossRefGoogle Scholar
Moldin, SO, Gottesman, IIGenes, experience, and chance in schizophrenia–positioning for the 21st century. Schizophr Bull 1997;23:547–561.CrossRefGoogle ScholarPubMed
Mostello, D, Catlin, TK, Roman, L, Holcomb, WL, Leet, TPreeclampsia in the parous woman: who is at risk?. Am J Obstet Gynecol 2002;187:425–429.CrossRefGoogle ScholarPubMed
Nelson, K, JH, EAntecedents of cerebral palsy. Multivariate analysis of risk. N Engl J Med 1986;315:81–86.CrossRefGoogle ScholarPubMed
Nilsson, E, Lichtenstein, P, Cnattingius, S, Murray, RM, Hultman, CMWomen with schizophrenia: pregnancy outcome and infant death among their offspring. Schizophr Res 2002;58:221–229.CrossRefGoogle ScholarPubMed
Nurnberger, JI, Blehar, MC, Kaufmann, CA, York-Cooler, C, Simpson, SG, Harkavy-Friedman, Jet al.Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative. Arch Gen Psychiatr 1994;51:849–859.CrossRefGoogle ScholarPubMed
O’Callaghan, E, Gibson, T, Colohan, HA, Buckley, P, Walshe, DG, Larkin, Cet al.Risk of schizophrenia in adults born after obstetric complications and their association with early onset of illness–a controlled-study. BM 1992;305:1256–1259.10.1136/bmj.305.6864.1256CrossRefGoogle ScholarPubMed
O’Callaghan, E, Larkin, C, Kinsella, A, Waddington, JLObstetric complications, the putative familial-sporadic distinction, and tardive dyskinesia in schizophrenia. Br J Psychiatr 1990;157:578–584.CrossRefGoogle Scholar
O’Callaghan, E, Larkin, C, Waddington, JLObstetric complications in schizophrenia and the validity of maternal recall. Obstetric complications in schizophrenia and the validity of maternal recall. Psychol Me 1990;20:89–94.CrossRefGoogle ScholarPubMed
Peacock, JL, Bland, JM, Anderson, HRPreterm delivery: effects of socioeconomic factors, psychological stress, smoking, alcohol, and caffeine. BM 1995;311:531–535.CrossRefGoogle ScholarPubMed
Rosso, IM, Cannon, TD, Huttunen, T, Huttunen, MO, Lonnqvist, J, Gasperoni, TLObstetric risk factors for early-onset schizophrenia in a Finnish birth cohort. Am J Psychiat 2000;157:801–807.CrossRefGoogle Scholar
Roy, M, Crowe, RValidity of the familial and sporadic subtypes of schizophrenia. Am J Psychiat 1994;151:805–814.Google ScholarPubMed
Sacker, A, Done, D, Crow, TObstetric complications in children born to parents with schizophrenia: a meta-analysis of case-control studies. Psychol Med 1996;26:279–287.CrossRefGoogle ScholarPubMed
Seidman, LJ, Faraone, SV, Goldstein, JM, Kremen, WS, Horton, NJ, Makris, Net al.Left hippocampal volume as a vulnerability indicator for schizophrenia: A magnetic resonance imaging morphometric study of nonpsychotic first-degree relatives. Arch Gen Psychiatr 2002;59:839–849.CrossRefGoogle ScholarPubMed
Sham, PC, Jones, P, Russell, A, Gilvarry, K, Bebbington, P, Lewis, Set al.Age at onset, sex, and familial psychiatric morbidity in schizophrenia–Camberwell collaborative psychosis study. Br J Psychiatr 1994;165:466–473.CrossRefGoogle ScholarPubMed
Spitzer, R, Endicott, JSchedule for affective disorders and schizophrenia—lifetime versio New York: New York State Psychiatric Institute; 1978.Google Scholar
Tsuang, MT, Stone, WS, Faraone, SVGenes, environment and schizophrenia. Br J Psychiatr 178Suppl. 402001 s18–s24.CrossRefGoogle Scholar
Verdoux, H, Geddes, JR, Takei, N, Lawrie, SM, Bovet, P, Eagles, JMet al.Obstetric complications and age at onset in schizophrenia: an international collaborative meta-analysis of individual patient data. Am J Psychiat 1997;154:1220–1227.Google ScholarPubMed
Woerner, MG, Pollack, M, Klein, DFPregnancy and birth complications in psychiatric patients: a comparison of schizophrenic and personality disorder patients with their siblings. Acta Psychiatr Scand 1973;49:712–721.CrossRefGoogle ScholarPubMed
Yawn, BP, Suman, VJ, Jacobsen, SJMaternal recall of distant pregnancy events. J Clin Epidemiol 1998;51:399–405.CrossRefGoogle ScholarPubMed
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