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O-51 - Axis I Diagnoses and Transition to Psychosis in Clinical High-risk Patients

Published online by Cambridge University Press:  15 April 2020

R.K.R. Salokangas ,
S. Ruhrmann ,
H. Graf von Reventlow ,
M. Heinimaa ,
T. Svirskis ,
S. Luutonen ,
G. Juckel ,
D. Linszen ,
P. Dingemans  and
M. Birchwood
...Show all authors
R.K.R. Salokangas
Affiliation:
Department of Psychiatry, University of Turku, Turku, Finland
S. Ruhrmann
Affiliation:
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne
H. Graf von Reventlow
Affiliation:
Department. of Psychiatry, Psychotherapy and Psychosomatic Medicine, Ruhr-University Bochum, Bochum, Germany
M. Heinimaa
Affiliation:
Department of Psychiatry, University of Turku, Turku, Finland
T. Svirskis
Affiliation:
Department of Psychiatry, University of Helsinki, Helsinki, Finland
S. Luutonen
Affiliation:
Department of Psychiatry, University of Turku, Turku, Finland
G. Juckel
Affiliation:
Department. of Psychiatry, Psychotherapy and Psychosomatic Medicine, Ruhr-University Bochum, Bochum, Germany
D. Linszen
Affiliation:
Acadmic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
P. Dingemans
Affiliation:
Acadmic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
M. Birchwood
Affiliation:
Early Intervention Service, University of Birmingham, Birmingham, UK
P. Patterson
Affiliation:
Early Intervention Service, University of Birmingham, Birmingham, UK
J. Klosterkötter
Affiliation:
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne

Abstract

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Introduction

A considerable number of patients at clinical high risk of psychosis (CHR) are found to meet criteria for co-morbid clinical psychiatric disorders.

Objectives

It is not known how clinical diagnoses correspond to transitions to psychosis (TTP).

Aims

We aimed to examine distributions of life-time and current Axis I diagnoses, and their association with TTP in CHR patients.

Methods

In the European Prediction of Psychosis Study project, 245 young help-seeking CHR patients were examined, and their baseline and life-time diagnoses were assessed by the Structured Clinical Interview for DSM-IV (SCID-I). TTP was defined by continuation of BLIPS for more than seven days.

Results

Altogether, 71 % of the CHR patients had one or more life-time and 62 % one or more current SCID-I diagnosis; about a half in each category received a diagnosis of life-time depressive and anxiety disorder. Currently, 34 % suffered from depressive, 39 % from anxiety disorder, 4 % from bipolar and 6.5 % from somatoform disorder. During follow-up, 37 (15.1 %) TTPs were identified. In multivariate Cox regression analyses, current bipolar disorder, somatoform and unipolar depressive disorders associated positively, and anxiety disorders negatively, with TTP.

Conclusions

Both life-time and current mood and anxiety disorders are highly prevalent among help-seeking CHR patients and need to be carefully evaluated. Among them, occurrence of bipolar, somatoform and depressive disorders seem to predict TTP, while anxiety disorder may predict non-transition to psychosis. Treatment of bipolar, somatoform and depressive disorders may prevent CHR patients from developing full-blown psychotic disorders.

Type
Abstract
Information
European Psychiatry , Volume 27 , Issue S1: Abstracts of the 20th European Congress of Psychiatry , 2012 , pp. 1
Copyright
Copyright © European Psychiatric Association 2012
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