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Next day effects after nighttime treatment with zolpidem: a review

Published online by Cambridge University Press:  16 April 2020

M Undén  and
B Roth Schechter
M Undén
Affiliation:
Sct Hans Hospital, Department M, 4000 Roskilde, Denmark
B Roth Schechter
Affiliation:
Boston Research and Science Consulting, Dover, MA02030, USA
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Summary

The purpose of this review was to analyze the literature for potential next-day residual effects of zolpidem, a non-benzodiazepine hypnotic, following nighttime administration. Based on more than 30 international clinical trials involving more than 2,600 subjects/patients, it can be concluded that at the recommended doses of zolpidem 10 mg for adults and zolpidem 5 mg for the elderly, at single or repeated dosing, in healthy subjects or insomniac patients, zolpidem appears to induce minimal next-day residual effects. As for all sedative hypnotics, zolpidem is indicated for the short-term treatment of insomnia and is recommended to be taken only when the patient is able to get a full night's sleep before resuming usual activities.

Keywords

zolpidembenzodiazepine I-receptoromega-I receptor selectivityshort actingresidual effectsmemory functionperformances
Type
Research Article
Information
European Psychiatry , Volume 11 , Issue S1: Sleep disorders: epidemiology, social impact and treatment attitudes - Symposium to the AEP Congress , 1996 , pp. 21s - 30s
Copyright
Copyright © 1996 Elsevier, Paris

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