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New functional single nucleotide polymorphism (Ala72Ser) in the comt gene is associated with aggressive behavior in male schizophrenia

Published online by Cambridge University Press:  16 April 2020

J.P. Hong ,
S.H. Chung  and
C.Y. Kim
J.P. Hong
Affiliation:
Department of Psychiatry, Asan Medical Center, Seoul, South Korea
S.H. Chung
Affiliation:
Department of Psychiatry, Asan Medical Center, Seoul, South Korea
C.Y. Kim
Affiliation:
Department of Psychiatry, Asan Medical Center, Seoul, South Korea

Abstract

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Background:

A new functional Single Nucleotide Polymorphism (Ala72Ser) in the COMT Gene was discovered recently. The purpose of our study is to examine the association between Ala72Ser and Val158Met functional polymorphisms in COMT gene and homicidal behavior in schizophrenia.

Methods:

DNA was genotyped for the Ala72Ser and Val158Met SNPs of the COMT gene in a sample of 90 schizophrenic patients who committed homicide (H-SCZ) and 83 schizophrenic patients who had never committed homicide (NH-SCZ).

Results:

A statistically significant difference was found in genotype distribution and allele frequencies in SNP Ala72Ser of COMT gene between H-SCZ and NH-SCZ group.. In haplotype analysis, the frequency of the combination of high-high activity allele (Ala-Val) was fewer in H-SCZ group than in NH-SCZ group (p=0.000657).

Conclusions:

Our study showed a highly significant association between a COMT haplotype of two functional SNP and aggressive behavior in schizophrenia.

Type
Poster Session 1: Schizophrenia and Other Psychosis
Information
European Psychiatry , Volume 22 , Issue S1: 15th AEP Congress - Abstract book - 15th AEP Congress , March 2007 , pp. S115
Copyright
Copyright © European Psychiatric Association 2007
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