Hostname: page-component-7bb8b95d7b-495rp Total loading time: 0 Render date: 2024-10-02T21:20:14.548Z Has data issue: false hasContentIssue false
  • English
  • Français

Neurotransmitters related to depression and psychosis in patients with temporal lobe epilepsy

Published online by Cambridge University Press:  16 April 2020

E.A. Scherer ,
D.L.G. Gitaí ,
J. Brusco ,
A.K.B. Lucio-Eterovic ,
V.D.S.S. Andrade ,
C.G. Carlotti Junior ,
J.E.C. Hallak ,
J.P. Leite ,
J.E. Moreira  and
FAPESP/CNPq
E.A. Scherer
Affiliation:
Department of Neurosciences and Behavioral Sciences, Ribeirão Preto Medical School Hospital of the University of São Paulo, Ribeirão Preto, Brazil
D.L.G. Gitaí
Affiliation:
Department of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto, Brazil
J. Brusco
Affiliation:
Department of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto, Brazil
A.K.B. Lucio-Eterovic
Affiliation:
Department of Pediatrics, Ribeirão Preto Medical School of the University of São Paulo, Ribeirão Preto, Brazil
V.D.S.S. Andrade
Affiliation:
Department of Pediatrics, Ribeirão Preto Medical School of the University of São Paulo, Ribeirão Preto, Brazil
C.G. Carlotti Junior
Affiliation:
Department of Surgery and Anatomy, Ribeirão Preto Medical School of the University of São Paulo, Ribeirão Preto, Brazil
J.E.C. Hallak
Affiliation:
Department of Neurosciences and Behavioral Sciences, Ribeirão Preto Medical School Hospital of the University of São Paulo, Ribeirão Preto, Brazil
J.P. Leite
Affiliation:
Department of Neurosciences and Behavioral Sciences, Ribeirão Preto Medical School Hospital of the University of São Paulo, Ribeirão Preto, Brazil
J.E. Moreira
Affiliation:
Department of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto, Brazil

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Introduction

Epilepsy affects between 1 and 2% of the world population. Drug refractoriness is common and about 40% of patients suffer from psychiatric disorders.

Objective

Knowing noradrenaline, dopamine, serotonin and substance P receptors’ role in hippocampi removed from people with temporal lobe epilepsy (TLE) with or without psychiatric comorbidity.

Aims

To assess whether there are differences in different neurotransmitters’ roles in TLE with or without psychiatric comorbidity.

Method

TacMan real-time PCR assay to quantify the receptors’ mRNA in 48 TLE patients without (Epilepsy-24) or with psychosis (Psychosis-10) or depression (Depression-14) and 8 necropsies (Controls).

Results

AD2A and AD2C showed differences and more expression in the Epilepsy group when compared with Control and Psychosis. AD2A showed significance in the Antiepileptic variable, a substance that activates AD2A in the hippocampus. AD2A and AD2C without difference for Epilepsy and Depression indicate a two-way relation or common pathogenesis between these illnesses; and their minor expression in the Psychosis group suggests different adrenergic mechanisms connected with psychosis and epilepsy. D2 showed a significant difference in the Psychiatric Diagnosis Subtype and Epileptic Seizures frequency, probably due to chronicity and number of depressive episodes. The role of 5-HT2A in TLE is indicated by its greater expression in the Epilepsy group when compared with the Control, with significance for the Epileptic Seizures frequency. No significant results were found for D4, 5-HT1A, 5-HT2C and NK1.

Conclusion

Prospective research with complementary methods (immunohistochemistry, in situ hybridization, electronic microscopy and neuroimaging) is suggested to identify, locate and visualize the receptors’ distribution.

Type
P02-313
Information
European Psychiatry , Volume 26 , Issue S2: Abstracts of the 19th European Congress of Psychiatry , March 2011 , pp. 909
Copyright
Copyright © European Psychiatric Association 2011
Submit a response

Comments

No Comments have been published for this article.