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Neuropsychological profile and correlation with outcomes in patients admitted to spdc

Published online by Cambridge University Press:  13 August 2021

M. Benassi ,
F. Ambrosini ,
R. Raggini ,
G. Piraccini  and
R. Sant’Angelo
M. Benassi
Affiliation:
Department Of Psychology, University of Bologna, Cesena, Italy
F. Ambrosini
Affiliation:
Psychologist, Independent Researcher, Savignano, Italy
R. Raggini
Affiliation:
Mental Health Department, AUSL ROMAGNA, Cesena, Italy
G. Piraccini
Affiliation:
Mental Health Department, AUSL ROMAGNA, Cesena, Italy
R. Sant’Angelo*
Affiliation:
Mental Health Department, AUSL ROMAGNA, Cesena, Italy
*
*Corresponding author.

Abstract

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Introduction

Literature showed that patients suffering from disorders belonging to the schizophrenic (SZ) and bipolar (DB) spectrum have a qualitatively similar but quantitatively different neurocognitive impairment that correlates with the outcomes. However, the majority of former studies are conducted on patients in remission phase.

Objectives

This study aims to compare cognitive functions between SZ and DB in the acute phase and their possible correlations with treatment outcomes.

Methods

In a prospective longitudinal study conducted at the SPDC Ausl unit of Romagna - Cesena, 57 SZ and 82 DB took part in the study. The diagnosis was based on the SCID5 CV and SCID5 DP. Symptom severity was assessed with BPRS and HONOS both at the beginning and at the end of hospitalization. Executive functions were measured with Tower of London (ToL) and Modified Wisconsin Card Sorting Test (MCST), attention with Attentive Matrices (MA) and Stroop Test (ST), non-verbal logic skills with Colored Matrices by Raven (PM47). The statistical analyzes applied are ANOVA and logistic regression.

Results

The cognitive tests did not reveal significant differences between SZ and DB. The logistic regression analysis showed that the scores obtained at the MCST and MA positively correlate with the efficacy of the treatment for both groups.

Conclusions

Cognition in DB and SZ patients was similarly impaired, supporting recent theories that placed diagnoses on a continuum of severity. Moreover, the results indicated that also in the acute phase the best predictors of the outcome were flexibility in problem solving strategies and visuospatial attention.

Disclosure

No significant relationships.

Keywords

Neuropsychological profilecognitive functionsproblem solvingoutcomes
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S134 - S135
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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