Hostname: page-component-586b7cd67f-dlnhk Total loading time: 0 Render date: 2024-11-27T01:03:00.739Z Has data issue: false hasContentIssue false
  • English
  • Français

Neuropsychological functioning in early-onset first-episode psychosis: lack of differences among diagnostic subgroups

Published online by Cambridge University Press:  16 April 2020

A. Zabala ,
I. Bombin ,
M. Rapado ,
P. Andres ,
C. Gonzalez ,
M. Mayoral ,
O. Robles ,
J.M. Rodriguez ,
E. de la Serna  and
C. Arango
A. Zabala
Affiliation:
Unidad de Adolescentes. Dpto Psiquiatria, Hospital General Universitario Gregorio Marañón, Madrid, Spain
I. Bombin
Affiliation:
Unidad de Adolescentes. Dpto Psiquiatria, Hospital General Universitario Gregorio Marañón, Madrid, Spain
M. Rapado
Affiliation:
Dpto Psiquiatria, Clinica Universitaria de Navarra, Navarra, Spain
P. Andres
Affiliation:
Dpto Psiquiatria, Hospital Infantil Universitario Niño Jesus, Madrid, Spain
C. Gonzalez
Affiliation:
Dpto Psiquiatria, Hospital Santiago Apóstol de Vitoria, Alava, Spain
M. Mayoral
Affiliation:
Unidad de Adolescentes. Dpto Psiquiatria, Hospital General Universitario Gregorio Marañón, Madrid, Spain
O. Robles
Affiliation:
Unidad de Adolescentes. Dpto Psiquiatria, Hospital General Universitario Gregorio Marañón, Madrid, Spain
J.M. Rodriguez
Affiliation:
Dpto Psiquiatria, Hospital Marques de Valdecilla, Cantabria, Spain
E. de la Serna
Affiliation:
Dpto Psiquiatria, Hospital Clinic de Barcelona, Barcelona, Spain
C. Arango
Affiliation:
Unidad de Adolescentes. Dpto Psiquiatria, Hospital General Universitario Gregorio Marañón, Madrid, Spain

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Cognitive impairment has been consistently described in adult-onset psychosis. A few studies have reported that cognitive impairment is present in early-onset schizophrenia. However, studies on other psychoses are lacking and little is known about the potential specificity of cognitive impairment patterns among the differential sub-diagnoses.

Aims:

1) To examine the nature and extent of cognitive impairment in first-episode early-onset psychosis (EOP) and 2) To search for differential cognitive impairment profiles among the diagnosis subgroups.

Methods:

This study describes the basal neuropsychological results of the child and adolescent first-episode psychosis study (CAFEPS), a spanish multicenter longitudinal study. One hundred first-episode patients with EOP and 98 healthy controls underwent a comprehensive neuropsychological assessment. Three diagnostic categories were established: schizophrenia spectrum disorders (n=45), affective psychosis (n=28), and psychosis not otherwise specified (n=28). Baseline diagnoses were confirmed at a 6-month follow-up visit.

Results:

Performance of patients was between 0.88 and 2 standard deviations below that of controls in all cognitive domains: attention (p<0.001), working memory (p<0.001), executive functioning (p<0.001), and memory (p<0.001). The three diagnostic subgroups did not differ from one another in terms of impaired/preserved cognitive functions and degree of impairment.

Conclusions:

The pattern and degree of cognitive impairment in first-episode EOP patients is similar to that reported in first-episode adult-onset patients. Our results failed to identify significant differences among diagnostic subgroups at the onset of the illness. The longitudinal design of the present study will allow for identification of potential differences in the course of cognitive impairment.

Type
Poster Session 1: Schizophrenia and Other Psychosis
Information
European Psychiatry , Volume 22 , Issue S1: 15th AEP Congress - Abstract book - 15th AEP Congress , March 2007 , pp. S145
Copyright
Copyright © European Psychiatric Association 2007
Submit a response

Comments

No Comments have been published for this article.