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Neuropsychological correlates of schizophrenic syndromes in patients treated with atypical neuroleptics

Published online by Cambridge University Press:  16 April 2020

S. Moritz ,
B. Andresen ,
D. Jacobsen ,
K. Mersmann ,
U. Wilke ,
M. Lambert ,
D. Naber  and
M. Krausz
S. Moritz*
Affiliation:
Universitäts-Krankenhaus Hamburg-Eppendorf, Klinik für Psychiatrie und Psychotherapie, Martinistraße 52, D-20246Hamburg, Germany
B. Andresen
Affiliation:
Universitäts-Krankenhaus Hamburg-Eppendorf, Klinik für Psychiatrie und Psychotherapie, Martinistraße 52, D-20246Hamburg, Germany
D. Jacobsen
Affiliation:
Universitäts-Krankenhaus Hamburg-Eppendorf, Klinik für Psychiatrie und Psychotherapie, Martinistraße 52, D-20246Hamburg, Germany
K. Mersmann
Affiliation:
Universitäts-Krankenhaus Hamburg-Eppendorf, Klinik für Psychiatrie und Psychotherapie, Martinistraße 52, D-20246Hamburg, Germany
U. Wilke
Affiliation:
Universitäts-Krankenhaus Hamburg-Eppendorf, Klinik für Psychiatrie und Psychotherapie, Martinistraße 52, D-20246Hamburg, Germany
M. Lambert
Affiliation:
Universitäts-Krankenhaus Hamburg-Eppendorf, Klinik für Psychiatrie und Psychotherapie, Martinistraße 52, D-20246Hamburg, Germany
D. Naber
Affiliation:
Universitäts-Krankenhaus Hamburg-Eppendorf, Klinik für Psychiatrie und Psychotherapie, Martinistraße 52, D-20246Hamburg, Germany
M. Krausz
Affiliation:
Universitäts-Krankenhaus Hamburg-Eppendorf, Klinik für Psychiatrie und Psychotherapie, Martinistraße 52, D-20246Hamburg, Germany
*
* Correspondence and reprints. E-mail address: [email protected] (S. Moritz).
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Summary

There is widespread evidence that schizophrenic symptomatology is best represented by three syndromes (positive, negative, disorganized). Both the disorganized and negative syndrome have been found to correlate with several neurocognitive dysfunctions. However, previous studies investigated samples predominantly treated with typical neuroleptics, which frequently induce parkinsonian symptoms that are hard to disentangle from primary negative symptoms and may have inflated correlations with neurocognition. A newly developed psychopathological instrument called the Positive and Negative and Disorganized Symptoms Scale (PANADSS) was evaluated in 60 schizophrenic patients. Forty-seven participants treated with atypical neuroleptics performed several neurocognitive tasks.

A three-factor solution of schizophrenic symptomatology emerged. Negative symptomatology was associated with diminished creative verbal fluency and digit span backward, whereas disorganization was significantly correlated with impaired Stroop, WCST and Trail-Making Test B performance.

Data suggest that disorganization is associated with tasks that demand executive functioning. Previous findings reporting correlations between negative symptomatology and neurocognition may have been confounded by the adverse consequences of typical neuroleptics.

Keywords

atypical neurolepticsdisorganizationnegative symptomsneuropsychologypositive symptoms
Type
Original article
Information
European Psychiatry , Volume 16 , Issue 6 , September 2001 , pp. 354 - 361
Copyright
Copyright © 2001 Éditions scientifiques et médicales Elsevier SAS. All rights reserved

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References

American Psychiatric Association. Diagnostic and statistical manual of mental disorders (DSM-IV). Washington, DC: APA; 1994.Google Scholar
Andreasen, NC.Scale for the Assessment of Negative Symptoms (SANS). Iowa City: University of Iowa; 1984.Google Scholar
Andreasen, NC.Scale for the Assessment of Positive Symptoms (SAPS). Iowa City: University of Iowa; 1984.Google Scholar
Andreasen, NCArndt, SAlliger, RMiller, DFlaum, M.Symptoms of schizophrenia. Methods, meanings, and mechanisms. Arch Gen Psychiatry 1995; 52: 341–51.CrossRefGoogle ScholarPubMed
Andreasen, NCFlaum, MSwayze, IIVWTyrrell, GArndt, S.Positive and negative symptoms in schizophrenia. Arch Gen Psychiatry 1990; 47: 615–21.CrossRefGoogle Scholar
Andreasen, NCOlsen, S.Negative vs positive schizophrenia. Arch Gen Psychiatry 1982; 39: 789–94.CrossRefGoogle Scholar
Andresen, BMoritz, S.Positive, Negative and Disorganized Symptoms Scale for Schizophrenia (PANADSS). Manual. Westerau (Germany): PPV; 2000.Google Scholar
Basso, MRNasrallah, HAOlson, SCBornstein, RA.Neuropsychological correlates of negative, disorganized and psychotic symptoms in schizophrenia. Schizophr Res 1998; 31: 99–111.CrossRefGoogle Scholar
Bäumler, G.Farbe-Wort-Interferenztest (FWIT) nach J. R. Stroop. Göttingen: Hogrefe; 1985.Google Scholar
Bilder, RMMukherjee, SRieder, ROPandurangi, AK.Symptomatic and neuropsychological components of defect states. Schizophr Bull 1985; 11: 409–19.CrossRefGoogle ScholarPubMed
Bortz, J.Statistik für Sozialwissenschaftler. Berlin: Springer; 1993.Google Scholar
Brekke, JSRaine, AThomson, C.Cognitive and psychophysiological correlates of positive, negative, and disorganized symptoms in the schizophrenia spectrum. Psychiatry Res 1995; 57: 241–50.CrossRefGoogle ScholarPubMed
Brown, KWWhite, T.The psychological consequences of tardive dyskinesia. The effect of drug-induced parkinsonism and the topography of the dyskinetic movements. Br J Psychiatry 1991; 159: 399–403.CrossRefGoogle ScholarPubMed
Brown, KWWhite, T.Syndromes of chronic schizophrenia and some clinical correlates. Br J Psychiatry 1992; 161: 317–22.CrossRefGoogle ScholarPubMed
Brown, KWWhite, TPalmer, D.Movement disorders and psychological tests of frontal lobe function in schizophrenic patients. Psychol M 1992; 22: 69–77.CrossRefGoogle ScholarPubMed
Carpenter, W.T.The treatment of negative symptoms: pharmacological and methodological issues. Br J Psychiatry 168Suppl 291996 17–22.CrossRefGoogle Scholar
Chapman, LJChapman, JPCurran, TEMiller, MB.Do children and the elderly show heightened semantic priming? How to answer the question. Dev Rev 1994; 14: 159–85.CrossRefGoogle Scholar
Crow, TJ.Molecular pathology of schizophrenia: more than one dimension of pathology. Br Med J 1980; 280: 66–8.CrossRefGoogle Scholar
Dietmaier, OLaux, G.Übersichtstabellen. Riederer, PLaux, GPöldinger, W, Eds.; Neuro-Psychopharmaka, Band 4. Wien: Springer; 1998. 505–22.CrossRefGoogle Scholar
Eaton, WWThara, RFederman, BMelton, BLiang, KY.Structure and course of positive and negative symptoms in schizophrenia. Arch Gen Psychiatry 1995; 52: 127–34.CrossRefGoogle Scholar
Gureje, OAderibigbe, YAObikoya, O.Three syndromes in schizophrenia: validity in young patients with recent onset of illness. Psychol M 1995; 25: 715–25.CrossRefGoogle ScholarPubMed
Hale, AS.A review of the safety and tolerability of sertindole. Int Clin Psychopharmacol 13Suppl 31998 65–70.CrossRefGoogle ScholarPubMed
Horn, W.Das Leistungsprüfsystem (L-P-S). Göttingen: Hogrefe; 1962.Google Scholar
Hornstein, CRichter, PMortimer, ABeuth, AMüller-Wulff, ISauer, H.Dimensionen der Schizophrenie im Alter. Korrelationen mit kognitiven und motorischen Auffälligkeiten. Nervenarzt 1998; 69: 243–8.CrossRefGoogle Scholar
Kaiser, HF.An index of factorial simplicity. Psychometrika 1974; 39: 31–6.CrossRefGoogle Scholar
Kay, SR.Significance of the positive-negative distinction in schizophrenia. Schizophr Bull 1990; 16: 635–52.CrossRefGoogle Scholar
Kay, SROpler, LALindenmayer, J-P.The positive and negative syndrome scale (PANSS). Rationale and standardisation. Br J Psychiatry 155Suppl 71989 59–65.CrossRefGoogle Scholar
Krausz, MMoritz, SHNaber, DLambert, MAndresen, B.Neuroleptic-induced extrapyramidal symptoms are accompanied by cognitive dysfunction in schizophrenia. Eur Psychiatry 1999; 14: 84–8.CrossRefGoogle Scholar
Lehrl, S.Mehrfachwahl-Wortschatz-Intelligenztest: MWT-B. Balingen: PERIMED-spitta; 1995.Google Scholar
Liddle, PF.The symptoms of chronic schizophrenia. A re-examination of the positive-negative dichotomy. Br J Psychiatry 1987; 151: 145–51.CrossRefGoogle ScholarPubMed
Liddle, PF.Schizophrenic syndromes, cognitive performance and neurological dysfunction. Psychol M 1987; 17: 49–57.CrossRefGoogle ScholarPubMed
Liddle, PF.Volition and schizophrenia. David, ASCutting, JC, Eds.; The neuropsychology of schizophrenia. Hillsdale (NJ): Erlbaum; 1994. 39–49.Google Scholar
Liddle, PF.Inner connections within domain of dementia praecox: role of supervisory mental processes in schizophrenia. Eur Arch Psychiatry Clin Neurosci 1995; 245: 210–5.CrossRefGoogle Scholar
Liddle, PFCarpenter, WTCrow, T.Syndromes of schizophrenia. Classic literature. Br J Psychiatry 1994; 165: 721–7.CrossRefGoogle ScholarPubMed
Liddle, PFFriston, KJFrith, CDFrackowiak, RSJ.Cerebral blood flow and mental processes in schizophrenia. J Royal Soc M 1992; 85: 224–7.Google Scholar
Liddle, PFMorris, DL.Schizophrenic syndromes and frontal lobe performance. B J Psychiatry 1991; 158: 340–5.CrossRefGoogle ScholarPubMed
Lingjaerde, OAhlfors, UGBech, PDencker, SJElgen, K.The UKU side effect rating scale. A new comprehensive rating scale for psychotropic drugs and a cross-sectional study of side effects in neuroleptic-treated patients. Acta Psychiatr Scand 1987; 334: 1–100.CrossRefGoogle Scholar
Loong, J.The Wisconsin Card Sorting Test. San Luis Obispo (CA): Wang Neuropsychological Laboratory; 1990.Google Scholar
Mahurin, RKVelligan, DIMiller, AL.Executive-frontal lobe dysfunction in schizophrenia: a symptom subtype analysis. Psychiatry Res 1998; 79: 139–49.CrossRefGoogle ScholarPubMed
Marneros, ARohde, ADeister, A.Validity of the negative/positive dichotomy of schizophrenic disorders under long-term conditions. Psychopathology 1995; 28: 32–7.CrossRefGoogle ScholarPubMed
Mass, RSchoemig, THitschfeld, KWall, EHaasen, C.Psychopathological syndromes of schizophrenia. Evaluation of the dimensional structure of the Positive and Negative Syndrome Scale (PANSS). Schizophrenia Bull 2000; 26: 167–77.CrossRefGoogle Scholar
McGuire, PKSilbersweig, DAWright, IMurray, RMFrackowiak, RSJFrith, CD.The neural correlates of inner speech and auditory verbal imagery in schizophrenia: relationship to auditory verbal hallucinations. Br J Psychiatry 1996; 169: 148–59.CrossRefGoogle ScholarPubMed
Möller H-, J.The negative component in schizophrenia. Acta Psychiatr Scand 91Suppl 3881995 11–4.CrossRefGoogle Scholar
Moritz, SHMass, RJunk, U.Further evidence of reduced negative priming in positive schizotypy. Pers Ind Diff 1998; 24: 521–30.CrossRefGoogle Scholar
Norman, RMGMalla, AKMorrison-Stewart, SLHelmes, EWilliamson, PCThoams, J., et al. Neuropsychological correlates of syndromes in schizophrenia. Br J Psychiatry 1997; 170: 134–9.CrossRefGoogle Scholar
Reitan, RM.Trail Making Test. Manual for administration and scoring. South Tucson (AZ): Reitan Neuropsychology Laboratory; 1992.Google Scholar
Roder, VBrenner, HDKienzle, NHodel, B.IPT. Integriertes Psychologisches Therapieprogramm für schizophrene Probanden. Weinheim: Beltz; 1997.Google Scholar
Salokangas, RKR.Structure of schizophrenic symptomatology and its changes over time: prospective factor-analytical study. Acta Psychiatr Scand 1997; 95: 32–9.CrossRefGoogle ScholarPubMed
Schooler, NR.Deficit symptoms in schizophrenia: negative symptoms versus neuroleptic-induced deficits. Acta Psychiatr Scand. 1994; 89 Suppl 380: 21–6.CrossRefGoogle Scholar
Schoppe, K.J.Verbaler Kreativitäts-Test (VKT). Göttingen: Hogrefe; 1975.Google Scholar
Stroop, JR.Studies of interference in serial and verbal reactions. J Exp Psychol 1935; 18: 643–62.CrossRefGoogle Scholar
Tran, PVDellva, MATollefson, GDBeasley, CMPotvin, JHKiesler, GM.Extrapyramidal symptoms and tolerability of olanzapine versus haloperidole in the acute treatment of schizophrenia. J Clin Psychiatry 1997; 58: 205–11.CrossRefGoogle Scholar
Wechsler, D.Wechsler Adult Intelligence Scale. New York: Psychological Corporation; 1955.Google Scholar
World Health Organization. International classification of psychiatric disorders (ICD-10). Göttingen: Huber; 1991.Google Scholar
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