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Neurological soft signs in adolescents with first episode psychosis

Published online by Cambridge University Press:  16 April 2020

Arantzazu Zabala ,
Olalla Robles ,
Mara Parellada ,
Dolores Maria Moreno ,
Ana Ruiz-Sancho ,
Maite Burdalo ,
Oscar Medina  and
Celso Arango
Arantzazu Zabala*
Affiliation:
Unidad de Adolescentes, Departamento de Psiquiatría, Hospital General Universitario Gregorio Marañón, C/Ibiza 43, 28009Madrid, Spain
Olalla Robles
Affiliation:
Unidad de Adolescentes, Departamento de Psiquiatría, Hospital General Universitario Gregorio Marañón, C/Ibiza 43, 28009Madrid, Spain
Mara Parellada
Affiliation:
Unidad de Adolescentes, Departamento de Psiquiatría, Hospital General Universitario Gregorio Marañón, C/Ibiza 43, 28009Madrid, Spain
Dolores Maria Moreno
Affiliation:
Unidad de Adolescentes, Departamento de Psiquiatría, Hospital General Universitario Gregorio Marañón, C/Ibiza 43, 28009Madrid, Spain
Ana Ruiz-Sancho
Affiliation:
Unidad de Adolescentes, Departamento de Psiquiatría, Hospital General Universitario Gregorio Marañón, C/Ibiza 43, 28009Madrid, Spain
Maite Burdalo
Affiliation:
Unidad de Adolescentes, Departamento de Psiquiatría, Hospital General Universitario Gregorio Marañón, C/Ibiza 43, 28009Madrid, Spain
Oscar Medina
Affiliation:
Unidad de Adolescentes, Departamento de Psiquiatría, Hospital General Universitario Gregorio Marañón, C/Ibiza 43, 28009Madrid, Spain
Celso Arango
Affiliation:
Unidad de Adolescentes, Departamento de Psiquiatría, Hospital General Universitario Gregorio Marañón, C/Ibiza 43, 28009Madrid, Spain
*
*Corresponding author. E-mail address: [email protected] (A. Zabala).
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Abstract

The purpose of this study is to determine the decrease of neurological soft signs (NSS) during adolescence and to compare this evolutionary process in two groups of adolescents with first episode psychosis: a) schizophrenia and b) non-schizophrenia patients. The structured neurological evaluation scale (NES) was administered to 24 adolescents with first episode psychosis. The number of NSS, the total and subscales scores were correlated with age in patients and in 39 healthy controls. Adolescents with first-episode psychosis had a higher prevalence of NSS than healthy controls; the schizophrenia patients (N = 9) scored higher than non-schizophrenia patients (N = 15). The number of NSS, total score and the scores on three of the four NES subscales correlated inversely with age in the healthy control group. No correlation was found for the schizophrenia group. For the non-schizophrenia group, a significant negative correlation was found only in one subscale. The decrease of NSS during adolescence in the healthy population but not in the patient groups with psychosis may be an indicator of a disturbance of brain processes that occurs during development. We did not find a clear pattern of NSS that distinguished schizophrenia from other psychoses.

Keywords

Neurological soft signsFirst episodePsychosisAdolescence
Type
Original articles
Information
European Psychiatry , Volume 21 , Issue 5 , July 2006 , pp. 283 - 287
Copyright
Copyright © Elsevier SAS 2006

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References

Browne, S., Clarke, M., Gervin, M., Lane, A., Waddington, J.L., Larkin, C.et al.Determinants of neurological dysfunction in first episode schizophrenia. Psychol. Med 2000;30:1433–1441.CrossRefGoogle ScholarPubMed
Buchanan, R.W., Heinrichs, D.W.The Neurological Evaluation Scale (NES): a structured instrument for the assessment of neurological signs in schizophrenia. Psychiatry Res 1989;27:335–350.CrossRefGoogle Scholar
Dazzan, P., Murray, R.M.Neurological soft signs in first-episode psychosis: a systematic review. Br. J. Psychiatry Suppl 2002;43:s50–s57.CrossRefGoogle ScholarPubMed
DeLisi, L.E.Is schizophrenia a lifetime disorder of brain plasticity, growth and aging?. Schizophr. Res 1997;23:119–129.CrossRefGoogle ScholarPubMed
Gupta, S., Andreasen, N.C., Arndt, S., Flaum, M., Schultz, S.K., Hubbard, W.C.et al.Neurological soft signs in neuroleptic-naive and neuroleptic-treated schizophrenic patients and in normal comparison subjects. Am. J. Psychiatry 1995;152:191–196.Google ScholarPubMed
Heinrichs, D.W., Buchanan, R.W.Significance and meaning of neurological signs in schizophrenia. Am. J. Psychiatry 1998;145:11–18.Google Scholar
Hollingshead, A., Redlich, F.In: Sons, J.W.Social Class and Mental Illness. New York: A Community Study; 1958.CrossRefGoogle Scholar
Karp, B.I., Garvey, M., Jacobsen, L.K., Frazier, J.A., Hamburger, S.D., Bedwell, J.S.et al.Abnormal neurologic maturation in adolescents with early-onset schizophrenia. Am. J. Psychiatry 2001;158:1958. p. 118–122.CrossRefGoogle ScholarPubMed
Krebs, M., Gut-Fayand, A., Bourdel, M., Dischamp, J., Olie, J.Validation and factorial structure of a standardized neurological examination assessing neurological soft signs in schizophrenia. Schizophr. Res 2000;45:245–260.CrossRefGoogle Scholar
Rossi, A., De Cataldo, S., Di Michele, V., Manna, V., Ceccoli, S., Stratta, P.et al.Neurological soft signs in schizophrenia. Br. J. Psychiatr 1990;157:735–739.CrossRefGoogle Scholar
Rubin, P., Vorstrup, S., Hemmingsen, R., Andersen, H.S., Bendsen, B.B., Stromso, N.et al.Neurological abnormalities in patients with schizophrenia or schizophreniform disorder at first admission to hospital: correlations with computerized tomography and regional cerebral blood flow findings. Acta Psychiatr. Scand 1994;90:385–390.CrossRefGoogle ScholarPubMed
Sanders, R.D., Keshavan, M.S., Schooler, N.R.Neurological examination abnormalities in neuroleptic-naive patients with first-break schizophrenia: preliminary results. Am. J. Psychiatr 1994;151:1231–1233.Google ScholarPubMed
Scheffer, R.E.Abnormal neurological signs at the onset of psychosis. Schizophr. Res 2004;70:19–26.CrossRefGoogle Scholar
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