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Neurobiologic basis of antidepressant safety profiles

Published online by Cambridge University Press:  16 April 2020

D Hackett  and
E Salinas
D Hackett
Affiliation:
Wyeth-Ayerst CRD, 80 Ave du President Wilson, 92031Paris la Defense cedex, France
E Salinas
Affiliation:
Wyeth-Ayerst CRD, 80 Ave du President Wilson, 92031Paris la Defense cedex, France
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Summary

Venlafaxine is a serotonin-noradrenaline reuptake inhibitor (SNRI) that has no affinity for muscarinic, adrenergic or histaminergic receptors. In short-term trials, the adverse effects that occurred more often with venlafaxine than with placebo included nausea, somnolence, dizziness, dry mouth, and sweating. Rapid titration of the dose of venlafaxine to higher levels appeared, not unexpectedly, to be associated with an increased incidence of side effects. Side effects that appeared to be dose related included insomnia, nausea and sexual dysfunction. The incidence of nausea and dizziness was highest during the first 2 or 3 weeks of therapy and decreased rapidly thereafter. Somnolence also decreased over time. At high doses blood pressure increases were reported in a small percent of patients on venlafaxine and antidepressant drugs but were uncommon at the venlafaxine dose of 75–150 mg daily. Studies with venlafaxine in healthy volunteers indicate a low potential for drug-drug interactions. Overdoses have been reported in 14 of 3,082 patients administered venlafaxine in clinical trials, and no deaths were reported among these patients. Overdoses of venlafaxine induced mainly drowsiness and lethargy.

Keywords

venlafaxineserotonin-noradrenaline reuptake inhibitorsafetyneurobiologic actions
Type
Research Article
Information
European Psychiatry , Volume 12 , Issue S4 , 1997 , pp. 301s - 306s
Copyright
Copyright © Elsevier, Paris 1997

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