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Monoamine oxidase a gene polymorphism associated with hostility in male population of 45-64 in Russia/Siberia

Published online by Cambridge University Press:  13 August 2021

V. Gafarov ,
E. Gromova ,
D. Panov ,
I. Gagulin ,
A. Gafarova  and
V. Maximov
V. Gafarov*
Affiliation:
Collaborative Laboratory Of Cardiovascular Diseases Epidemiology, Institute of Internal and Preventive Medicine - branch of Institute of Cytology and Genetics SB RAS, Novosibirsk, Russian Federation
E. Gromova
Affiliation:
Collaborative Laboratory Of Cardiovascular Diseases Epidemiology, Institute of Internal and Preventive Medicine - branch of Institute of Cytology and Genetics SB RAS, Novosibirsk, Russian Federation
D. Panov
Affiliation:
Collaborative Laboratory Of Cardiovascular Diseases Epidemiology, Institute of Internal and Preventive Medicine - branch of Institute of Cytology and Genetics SB RAS, Novosibirsk, Russian Federation
I. Gagulin
Affiliation:
Collaborative Laboratory Of Cardiovascular Diseases Epidemiology, Institute of Internal and Preventive Medicine - branch of Institute of Cytology and Genetics SB RAS, Novosibirsk, Russian Federation
A. Gafarova
Affiliation:
Collaborative Laboratory Of Cardiovascular Diseases Epidemiology, Institute of Internal and Preventive Medicine - branch of Institute of Cytology and Genetics SB RAS, Novosibirsk, Russian Federation
V. Maximov
Affiliation:
Collaborative Laboratory Of Cardiovascular Diseases Epidemiology, Institute of Internal and Preventive Medicine - branch of Institute of Cytology and Genetics SB RAS, Novosibirsk, Russian Federation
*
*Corresponding author.

Abstract

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Introduction

The presence of low-activity alleles of the MAOA gene increases the risk of hostility.

Objectives

To study the association of hostility with high and low-active variants of the MAOA gene in an open population of men 45-64 years.

Methods

Under the WHO International Program MONICA-psychosocial and HAPIEE a representative sample of men aged 45–64 years (n = 781 men, average age was 56.48 ± 0.2 years) examined in 2003-2005. All respondents independently completed a questionnaire on hostility. From the surveyed sample using the random number method 156 men were selected who were genotyped for MAOA-uVNTR polymorphism.

Results

It was found the level of hostility in the population of men was 60.3%. In persons with low-active alleles of the MAOA-L gene (allele 2 and 3) a high level of hostility was more common - 50.9%. The results of building a logistic regression model showed that the presence of low-active alleles (2; 3) of the MAOA gene increases the likelihood of hostility OR = 2,103 (95% CI 1,137-3,889, p = 0.018).

Conclusions

Our findings allow us to conclude that the low-active allele of the MAOA-L gene is associated with hostility.

Keywords

populationmenMAOA genehostility
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S439 - S440
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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