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Monitoring sertraline and clozapine levels

Published online by Cambridge University Press:  01 September 2022

A. Rodriguez Campos ,
L. Rodriguez Andrés ,
G. Medina Ojeda ,
I. Santos Carrasco ,
J. Gonçalves Cerejeira  and
A. Gonzaga
A. Rodriguez Campos*
Affiliation:
Hospital Clinico Universitario de Valladolid, Departamento De Psiquiatría, Valladolid, Spain
L. Rodriguez Andrés
Affiliation:
Hospital Clinico Universitario de Valladolid, Departamento De Psiquiatría, Valladolid, Spain
G. Medina Ojeda
Affiliation:
Hospital Clinico Universitario de Valladolid, Departamento De Psiquiatría, Valladolid, Spain
I. Santos Carrasco
Affiliation:
Clinical Hospital of Valladolid, Psychiatry, Valladolid, Spain
J. Gonçalves Cerejeira
Affiliation:
Hospital Clínico Universitario de Valladolid, Psychiatry, Valladolid, Spain
A. Gonzaga
Affiliation:
HOSPITAL CLINICO UNIVERSITARIO DE VALLADOLID, Psiquiatria, VALLADOLID, Spain
*
*Corresponding author.

Abstract

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Introduction

One of the most frequent side effects seen when prescribing sertraline and clozapine together is the appearance of a seizure crisis. This event is usually related to an increase of plasmatic concentration due to interactions of these drugs with blood components.

Objectives

To investigate the effects of clozapine when combined with other drugs, especially its effects increasing plasmatic concentration.

Methods

A patient was treated sith 300 mg/day of clozapine followed by a treatment with sertraline 50 mg/day, which increases plasmatic concentration. The combination of these treatments produced seizures. Other works published about interactions are reviewed.

Results

It is important to monitor clozapine dosages to avoid increasing plasmatic concentration, especially if other drugs that have this effect are also administered.

Conclusions

It is important to monitor clozapine dosages to avoid increasing plasmatic concentration, especially if other drugs that have this effect are also administered.

Disclosure

No significant relationships.

Keywords

sertraline clozapine side effects
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S718
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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