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Published online by Cambridge University Press: 23 March 2020
Cognitive processes are impaired in Schizophrenia (SKZ). The nature of such impairment escapes definition.
Identification of a genetic profile at risk of cognitive impairment.
Identifying a molecular pathways enriched for mutations associated with cognitive impairment.
Seven hundred and sixty-five individuals from the CATIE, M = 556, mean age = 40.93 ± 11.03 were included. Verbal memory was outcome. R and Plink served for the analyses. Inflation factor was controlled by lambda values. Input for the pathway analysis were SNPs associated with outcome (P < 0.05) genomewide.
Gender (male, P = 2.34e–05;t = –4.26) and years of education (P = 1.57e–03;t = 6.502) were associated with verbal memory. Inflammation and oxidation were associated with outcome (Table 1, adj_P < 0.01).
Being male and poorly educated were associated with poorer verbal memory. Inflammation and the arachidonic acid pathway were enriched in mutations associated with poorer verbal memory. This finding is in line with previous reports [1,2,3].
Table 1 Pathways enriched in association with verbal memory.
The authors have not supplied their declaration of competing interest.
Table 1 Pathways enriched in association with verbal memory.
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