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Midline anomalies and organic psychosis: congenital or degenerative? A cross-sectional study of 62 patients with Andermann syndrome

Published online by Cambridge University Press:  16 April 2020

MJ Filteau*
Affiliation:
Unité de neuropsychopharmacologie, Hôpital de l’Enfant-Jésus et Centre de recherche Université Laval-Robert Giffard
E Pourcher
Affiliation:
Unité de neuropsychopharmacologie, Hôpital de l’Enfant-Jésus et Centre de recherche Université Laval-Robert Giffard
RH Bouchard
Affiliation:
Unité de neuropsychopharmacologie, Hôpital de l’Enfant-Jésus et Centre de recherche Université Laval-Robert Giffard
P Baruch
Affiliation:
Unité de neuropsychopharmacologie, Hôpital de l’Enfant-Jésus et Centre de recherche Université Laval-Robert Giffard
J Mathieu
Affiliation:
Hôtel-Dieu de Chicoutimi, Québec, Canada
F Bédard
Affiliation:
Unité de neuropsychopharmacologie, Hôpital de l’Enfant-Jésus et Centre de recherche Université Laval-Robert Giffard
N Simard
Affiliation:
Hôtel-Dieu de Chicoutimi, Québec, Canada
P Vincent
Affiliation:
Unité de neuropsychopharmacologie, Hôpital de l’Enfant-Jésus et Centre de recherche Université Laval-Robert Giffard
*
*Correspondence and reprints: 1401 18e rue, Québec (QUÉ) G1J 1Z4, Canada
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Extract

Brain alterations have been sought since the beginning of the century to explain the ‘dementia’ of dementia præcox. Kraepelin suggested in 1913 that it might have its internal origins in early childhood, while Southard (1915) considered likely a congenital or early acquired basis for the development of the disease. Afterwards, degenerative processes were described for decades until neurodevelopmental theories emerged recently (Lewis, 1988).

Using pneumoencephalography, Jacobi and Winkler (1927) first reported that some patients with schizophrenia presented enlarged ventricles. Johnstone et al (1976, 1978), in CT-scan studies, observed an increase in mean lateral ventricular size in a group of institutionalized schizophrenic patients. This finding has been replicated by other studies (Weinberger et al, 1983) but challenged by others (Gluck et al, 1980; Jernigan et al, 1982).

Type
Original article
Copyright
Copyright © Elsevier, Paris 1992

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References

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