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Methylation Related to Perceived Parenting in Adolescents and its Association to Depressive Symptoms Two Years Later

Published online by Cambridge University Press:  23 March 2020

E. Van Assche ,
E. Vangeel ,
K. Freson ,
K. Van Leeuwen ,
K. Verschueren ,
H. Colpin ,
W. Van den Noortgate ,
L. Goossens  and
S. Claes
E. Van Assche
Affiliation:
KU Leuven, neuroscience, Leuven, Belgium
E. Vangeel
Affiliation:
KU Leuven, neuroscience, Leuven, Belgium
K. Freson
Affiliation:
KU Leuven, center for molecular and vascular biology, Leuven, Belgium
K. Van Leeuwen
Affiliation:
KU Leuven, parenting and special education, Leuven, Belgium
K. Verschueren
Affiliation:
KU Leuven, school psychology and child and adolescent development, Leuven, Belgium
H. Colpin
Affiliation:
KU Leuven, school psychology and child and adolescent development, Leuven, Belgium
W. Van den Noortgate
Affiliation:
KU Leuven, methodology of educational sciences, Leuven, Belgium
L. Goossens
Affiliation:
KU Leuven, school psychology and child and adolescent development, Leuven, Belgium
S. Claes
Affiliation:
KU Leuven, neuroscience, Leuven, Belgium

Abstract

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Introduction

Adolescents’ well being is affected by their parenting situation and can influence their well being over time. We present an exploratory study with an Illumina 450 k array, comparing methylation in adolescents, based on perceived parenting at T0, and how methylation can interact with parenting in explaining depressive symptoms two years later (T2).

Objectives

Identify differentially methylated regions (DMRs) associated with perceived parenting at T0 and investigate their association with depressive symptoms two years later.

Aims

An exploratory analysis evaluating the association between methylation and depressive symptoms longitudinally.

Methods

From two extreme parenting clusters: perceived supportive, and punishing neglecting, we randomly selected 44 adolescents (MAge = 14 at T0; 48%boys). The CES-D scale (Center for Epidemiologic Studies Depression Scale) assessed depressive symptoms. DMRs were identified based on the parenting clusters (DMRcate and comb-p) using llumina Infinium HumanMethylation 450 BeadChip data. Associations between the most significant CpG for each DMR and the depression score at T2, were calculated using linear regression analysis.

Results

We identified 17 DMRs, but only cg13306335 in PEX10 was associated with depressive symptoms at T2 (P = 0.0014, Bonferroni (17 tests): P < 0.0029). Additionally, an interaction between parenting at T0 and PEX10 methylation (T0) in explaining depressive symptoms (T2) can be suggested (P = 0.014).

Conclusions

We show that methylation at PEX10's most significant CpG is correlated with depressive symptoms at T2, these exploratory results also suggest a possible interaction between parenting and PEX10 methylation at T0 in association with depressive symptoms at T2. Validation in a larger sample is needed to support the role of methylation and its interactions in depression over time.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-Poster walk: Child and adolescent psychiatry – Part 5
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. S307
Copyright
Copyright © European Psychiatric Association 2017
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