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Metabolic dysregulation as predictor for the course of late-life depression

Published online by Cambridge University Press:  23 March 2020

R. Marijnissen ,
N. Vogelzangs ,
M. Mulder ,
R. van den Brink ,
H. Comijs  and
R. Oude Voshaar
R. Marijnissen*
Affiliation:
Wolfheze, NetherlandsWolfheze, Netherlands
N. Vogelzangs
Affiliation:
VU University Medical Center, Department of Psychiatry/GGZinGeest & Institute for Extramural Medical Research EMGO, Amsterdam, Netherlands
M. Mulder
Affiliation:
Arnhem, NetherlandsArnhem, Netherlands
R. van den Brink
Affiliation:
University Medical Center Groningen- University of Groningen, University Center of Psychiatry & Interdisciplinary Center for Psychopathology of Emotion Regulation, Groningen, Netherlands
H. Comijs
Affiliation:
VU University Medical Center, Department of Psychiatry/GGZinGeest & Institute for Extramural Medical Research EMGO, Amsterdam, Netherlands
R. Oude Voshaar
Affiliation:
University Medical Center Groningen- University of Groningen, University Center of Psychiatry & Interdisciplinary Center for Psychopathology of Emotion Regulation, Groningen, Netherlands
*
*Corresponding author.

Abstract

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Introduction

Depression is associated with the metabolic syndrome (MS). Recently, the concept of ‘metabolic depression’ has been proposed based on a protracted course of depressive symptoms over time.

Objective and aims

Within the Netherlands study of depression in older persons, we examined whether metabolic dysregulation predicted the two-year course of depression.

Methods

A cohort study (n = 285) of depressed persons (≥60 years) with two-year follow up. Depression was classified according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV). Severity of depression was assessed with sum score as well as subscale scores of the Inventory of Depressive Symptomatology (IDS) at six-month intervals. The metabolic syndrome was defined according the National Cholesterol Education Program (NCEP-ATP III). We applied logistic regression and linear mixed models adjusted for a wide range of confounders and severity of depression at baseline.

Results

The number of MS-components predicted non-remission at two-years (OR = 1.28 [95% CI: 1.00–1.58], P = 0.047), which was driven by waist-circumference, HDL-cholesterol and triglycerides. MS was only associated with the somatic symptom subscale score of the IDS over time, but not with its sum score (interaction time × somatic subscale, P = 0.002). This effect was driven by waist circumference, elevated fasting glucose level and hypertension.

Conclusion

Metabolic dysregulation predicts the course of late-life depression. This effect seems to be driven by visceral obesity (as indicated by the waist circumference) and lipid dysregulations and with respect to the somatic symptoms of depression.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
EV519
Information
European Psychiatry , Volume 33 , Issue S1: Abstracts of the 24th European Congress of Psychiatry , March 2016 , pp. S416
Copyright
Copyright © European Psychiatric Association 2016
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