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Low-dose neuroleptic therapy and relapse in schizophrenia: meta-analysis of randomized controlled trials

Published online by Cambridge University Press:  16 April 2020

C Barbui ,
B Saraceno ,
A Liberati  and
S Garattini
C Barbui
Affiliation:
“Mario Negri” Institute for Pharmacological Research, Via Eritrea 62,20157Milan, Italy
B Saraceno
Affiliation:
“Mario Negri” Institute for Pharmacological Research, Via Eritrea 62,20157Milan, Italy
A Liberati
Affiliation:
“Mario Negri” Institute for Pharmacological Research, Via Eritrea 62,20157Milan, Italy
S Garattini
Affiliation:
“Mario Negri” Institute for Pharmacological Research, Via Eritrea 62,20157Milan, Italy
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Summary

We assessed the relative efficacy and effectiveness of low-versus standard-dose neuroleptic therapy in reducing relapse rate in schizophrenic patients. Six long-term randomized controlled trials were retrieved through a MEDLINE search. A dose regimen between 50 and 100 mg equivalent of chlorpromazine, compared to a conventional one between 200 and 500 mg, was found to increase the likelihood of relapse in chronic schizophrenic patients. Differences, however, were statistically significant at 12 but not at 24 months of treatment.

Keywords

schizophrenianeurolepticslow-dosemeta-analysis
Type
Original article
Information
European Psychiatry , Volume 11 , Issue 6 , 1996 , pp. 306 - 313
Copyright
Copyright © Elsevier, Paris 1996

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